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Ahmed M Hagag, JIE WANG, Terry Wood, Joseph Michael Simonett, Gareth Harman, Kevin Liu, David Huang, Richard G Weleber, Mark E Pennesi, Paul Yang, Yali Jia; Projection-Resolved Optical Coherence Tomography Angiography of Retinal Plexusess in Retinitis Pigmentosa and Usher Syndrome Type 1. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2842.
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Use of Projection-resolved Optical Coherence Tomography Angiography (PR-OCTA) to investigate the microvascular changes in three retinal plexuses in retinitis pigmentosa (RP) and Usher syndrome type 1 patients
A commercial 70-kHz spectral-domain OCT system (RTVue-XR, Optovue) was used to acquire 6mm macular scans from RP and Usher patients, as well as healthy controls. Blood flow was detected using split-spectrum amplitude-decorrelation algorithm (SSADA). PR-OCTA algorithm was used to suppress projection artifacts and resolve microvasculature in three plexuses at the macula. Vessel density was calculated from en face OCTA of the parafoveal and perifoveal regions in each of the three plexuses, as well as from the all-plexus inner retinal slab
46 eyes from 28 RP patients, 10 eyes from 10 Usher patients, and 34 eyes from 28 healthy volunteers were included. Significant reduction in vessel density was detected in the perifoveal region but not the parafovea of inner retinal slab of RP (p=0.001 and 0.58, respectively) and Usher (p=0.001 and 0.06, respectively) patients compared to controls (Table1). We also found deeper retinal plexuses (intermediate and deep capillary plexuses, ICP and DCP) were primarily damaged by RP and Usher syndrome, compared to the superficial vascular complex (SVC) (Figure1)
PR-OCTA enables the detection of microvascular changes in the perifoveal regions of the ICP and DCP in RP and Usher syndrome type 1 patients, with relative sparing of the SVC
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
Projection-resolved optical coherence tomography angiograms from a healthy subject (A), retinitis pigmentosa (RP)(B), and Usher syndrome type 1 patients (C). (A1-C1): En face structural OCT image. The red line corresponds to the cross-sectional OCT image in A2-C2. Angiography signal is color coded (red) and overlaid on the gray-scale structural OCT B-scan. Colored lines represent the boundaries of retinal plexuses in A3-A6, B3-B6, C3-C6. (A3-C3): All-plexus inner retinal slab with depth-oriented color-coded retinal plexuses. Purple vessels represent the superficial vascular complex (SVC, A4-C4). Green flow signal corresponds to the intermediate capillary plexus (ICP, A5-C5). Blue signal represents the deep capillary plexus (DCP, A6-C6). Note the vascular attenuation in the more peripheral regions of the ICP and DCP in RP and Usher patients compared to the healthy control
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