July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Projection-Resolved Optical Coherence Tomography Angiography of Retinal Plexusess in Retinitis Pigmentosa and Usher Syndrome Type 1
Author Affiliations & Notes
  • Ahmed M Hagag
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States
  • JIE WANG
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States
  • Terry Wood
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States
  • Joseph Michael Simonett
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States
  • Gareth Harman
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States
  • Kevin Liu
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States
    Donald and Barbara Zucker School of Medicine, Hempstead, New York, United States
  • David Huang
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States
  • Richard G Weleber
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States
  • Mark E Pennesi
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States
  • Paul Yang
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States
  • Yali Jia
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Ahmed Hagag, None; JIE WANG, None; Terry Wood, None; Joseph Simonett, None; Gareth Harman, None; Kevin Liu, None; David Huang, Optovue, Inc. (F), Optovue, Inc. (I), Optovue, Inc. (P), Optovue, Inc. (R); Richard Weleber, None; Mark Pennesi, None; Paul Yang, None; Yali Jia, Optovue, Inc. (F), Optovue, Inc. (P)
  • Footnotes
    Support  Grants R01 EY027833, DP3 DK104397, R01 EY024544, P30 EY010572, and K08 EY026650 from the NIH, an unrestricted departmental funding grant and William & Mary Greve Special Scholar Award from Research to Prevent Blindness, Foundation Fighting Blindness Career Development Award CD-NMT-0714-0648, Foundation Fighting Blindness C-CL-0711-0534-OHSU01
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2842. doi:
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    • Get Citation

      Ahmed M Hagag, JIE WANG, Terry Wood, Joseph Michael Simonett, Gareth Harman, Kevin Liu, David Huang, Richard G Weleber, Mark E Pennesi, Paul Yang, Yali Jia; Projection-Resolved Optical Coherence Tomography Angiography of Retinal Plexusess in Retinitis Pigmentosa and Usher Syndrome Type 1. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2842.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Use of Projection-resolved Optical Coherence Tomography Angiography (PR-OCTA) to investigate the microvascular changes in three retinal plexuses in retinitis pigmentosa (RP) and Usher syndrome type 1 patients

Methods : A commercial 70-kHz spectral-domain OCT system (RTVue-XR, Optovue) was used to acquire 6mm macular scans from RP and Usher patients, as well as healthy controls. Blood flow was detected using split-spectrum amplitude-decorrelation algorithm (SSADA). PR-OCTA algorithm was used to suppress projection artifacts and resolve microvasculature in three plexuses at the macula. Vessel density was calculated from en face OCTA of the parafoveal and perifoveal regions in each of the three plexuses, as well as from the all-plexus inner retinal slab

Results : 46 eyes from 28 RP patients, 10 eyes from 10 Usher patients, and 34 eyes from 28 healthy volunteers were included. Significant reduction in vessel density was detected in the perifoveal region but not the parafovea of inner retinal slab of RP (p=0.001 and 0.58, respectively) and Usher (p=0.001 and 0.06, respectively) patients compared to controls (Table1). We also found deeper retinal plexuses (intermediate and deep capillary plexuses, ICP and DCP) were primarily damaged by RP and Usher syndrome, compared to the superficial vascular complex (SVC) (Figure1)

Conclusions : PR-OCTA enables the detection of microvascular changes in the perifoveal regions of the ICP and DCP in RP and Usher syndrome type 1 patients, with relative sparing of the SVC

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

 


Projection-resolved optical coherence tomography angiograms from a healthy subject (A), retinitis pigmentosa (RP)(B), and Usher syndrome type 1 patients (C). (A1-C1): En face structural OCT image. The red line corresponds to the cross-sectional OCT image in A2-C2. Angiography signal is color coded (red) and overlaid on the gray-scale structural OCT B-scan. Colored lines represent the boundaries of retinal plexuses in A3-A6, B3-B6, C3-C6. (A3-C3): All-plexus inner retinal slab with depth-oriented color-coded retinal plexuses. Purple vessels represent the superficial vascular complex (SVC, A4-C4). Green flow signal corresponds to the intermediate capillary plexus (ICP, A5-C5). Blue signal represents the deep capillary plexus (DCP, A6-C6). Note the vascular attenuation in the more peripheral regions of the ICP and DCP in RP and Usher patients compared to the healthy control


Projection-resolved optical coherence tomography angiograms from a healthy subject (A), retinitis pigmentosa (RP)(B), and Usher syndrome type 1 patients (C). (A1-C1): En face structural OCT image. The red line corresponds to the cross-sectional OCT image in A2-C2. Angiography signal is color coded (red) and overlaid on the gray-scale structural OCT B-scan. Colored lines represent the boundaries of retinal plexuses in A3-A6, B3-B6, C3-C6. (A3-C3): All-plexus inner retinal slab with depth-oriented color-coded retinal plexuses. Purple vessels represent the superficial vascular complex (SVC, A4-C4). Green flow signal corresponds to the intermediate capillary plexus (ICP, A5-C5). Blue signal represents the deep capillary plexus (DCP, A6-C6). Note the vascular attenuation in the more peripheral regions of the ICP and DCP in RP and Usher patients compared to the healthy control

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