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Katia Santos, Natasha Cruz, Mateus Matuoka, Niro Kasahara; Correlation between the estimated intracranial pressure and glaucomatous optic neuropathy severity. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3701. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Clinical variables such as the intracranial pressure (ICP) could play a role in the glaucomatous optic neuropathy. Previous studies have shown that glaucoma patients have lower ICP as compared to normal controls. This was an observational, cross-sectional clinical study to correlate the estimated measurement of ICP with the severity of glaucomatous optic neuropathy.
The sample comprised 75 patients with open angle glaucoma. All participants underwent a complete ophthalmologic examination, automated perimetry, optical coherence tomography and clinical measurements (blood pressure, height, and weight), The ICP was estimated according to a formula and the correlation between ICP with structural (cup-to disc ratio and retinal nerve fiber layer) and functional parameters (MD and VFI) was evaluated with the Pearson's correlation coefficient using a linear and a non-linear regression model.This study was conducted in compliance with the Declaration of Helsinki.
Demographic data and clinical differences stratified by optic disc size are presented on table 1. ICP was inversely related to the cup-to-disc ratio (r = -0.563 [95%CI, -0.705 to -0.379], p < 0.0001) but had a positive relationship with nerve fiber layer (r = 0.441 [95%CI, 0.230 to 0.612], p = 0,0001) and functional parameters - MD (r = 0.280 [95%CI, 0.050 to 0.482], p = 0,0178) and VFI (r = 0.275 [95%CI, 0.035 to 0.485], p = 0,0253)..
The results of this study concurs with the hypothesis that glaucoma patients with more advanced disease have lower ICP. The implications of this finding is yet to be determined but may contribute to the development of new glaucoma treatment strategies that directly address the role of ICP
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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