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Do Yeh Yoon, Hyun Sun Jeon, Won Ryang Wee, Joon-Young Hyon; Correlation Between Noninvasive Tear Break-up Time and Ocular Parameters of Dry Eye Syndrome. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4883. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the relationship between noninvasive tear break-up time and ocular parameters of dry eye syndrome
Medical record of a total of 45 patients with dry eye syndrome were reviewed. Noninvasive keratograph break-up time (NIKBUT) using Oculus® Keratograph 5M and dry eye parameters such as tear break-up time (TBUT), ocular staining score (Sjögren's International Collaboration Clinical Alliance (SICCA) ocular staining score), Schirmer-I score, lipid layer thickness (measured with LipiView®) were obtained. Systemic laboratory data and medication history were also collected. Correlation between the parameters were analyzed by Mann-Whitney test.
45 patients with mean age of 60.0 ± 13.8 years and female predominance (77.78%) were enrolled. 15.56% of patients were diagnosed with rheumatologic disorder. The median NIKBUT was 8.0 ± 6.0 seconds, and average TBUT was 2.1 ± 1.1 seconds. Median NIKBUT of aqueous deficient type (Schirmer =< 5 mm/5min) dry eye patients were shorter than that of evaporative type (Schirmer > 5 mm/5min) dry eye patients (4.7653, 9.0296 seconds, respectively. p=0.023). Corneal surface parameters such as ocular staining score were not correlated with NIKBUT.
NIKBUT is correlated with the severity of dry eye especially in aqueous deficient type. Although Kertaograph® is used to assess tear film breakdown time, the corneal surface state does not affect the outcome.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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