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Natasha Cruz, Katia Santos, Mateus Matuoka, Niro Kasahara; Translaminar pressure gradient and ocular perfusion pressure in glaucoma patients with different optic disc sizes. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5085. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
The optic disc size varies largely in the population. Clinical variables such as the translaminar pressure gradient (TPG) - difference between intraocular and intracranial pressure - and the ocular perfusion pressure (OPP) play a role in the glaucomatous optic neuropathy. Uncertainty exists as to if these variables differ according to the optic disc size. This was an observational, cross-sectional clinical study to evaluate whether TPG and OPP varies in glaucoma patients with different optic disc sizes.
The sample comprised 75 patients with open angle glaucoma. All patients underwent an ophthalmic evaluation, clinical measurements (blood pressure, height, and weight), and optical coherence tomography examination. TPG and OPP were calculated for each patient using proxy algorithms to attain indirect surrogate parameter values. Optic disc sizes were stratified according to 3 quantiles and the differences compared with ANOVA test. Data from both eyes were used after using the appropriate correction for inter-eye dependency.
Demographic data are presented on table 1. The TPG did not vary between large and small discs; glaucoma patients with average disc sizes presented with higher TPG; the difference however, failed to reach statistical significance. Glaucoma patients with large disc size presented with higher OPP as compared to average sized discs (post hoc Tukey honest significant difference test P = 0.026).
Glaucoma patients with larger optic discs have higher OPP. The clinical significance of this finding is yet to be determined.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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