July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Visualization of Epiretinal Membrane Progression on En-Face OCT
Author Affiliations & Notes
  • Connie Wang
    Columbia University, New York, New York, United States
  • Katherine Tsang
    Columbia University, New York, New York, United States
  • Rashmi Rajshekhar
    Columbia University, New York, New York, United States
  • Robert Ritch
    The New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Jeffrey Odel
    Columbia University, New York, New York, United States
  • Stanley Chang
    Columbia University, New York, New York, United States
  • Donald C Hood
    Columbia University, New York, New York, United States
  • Footnotes
    Commercial Relationships   Connie Wang, None; Katherine Tsang, None; Rashmi Rajshekhar, None; Robert Ritch, None; Jeffrey Odel, None; Stanley Chang, None; Donald Hood, Heidelberg Engineering, Inc. (R), Heidelberg Engineering, Inc. (F), Heidelberg Engineering, Inc. (C), Topcon, Inc. (R), Topcon, Inc. (F), Topcon, Inc. (C)
  • Footnotes
    Support  NH Grant EY02115
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5269. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Connie Wang, Katherine Tsang, Rashmi Rajshekhar, Robert Ritch, Jeffrey Odel, Stanley Chang, Donald C Hood; Visualization of Epiretinal Membrane Progression on En-Face OCT. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5269.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To investigate the natural progression of epiretinal membranes (ERMs) visualized on swept source OCT (ssOCT) en-face images.

Methods : This is a retrospective study of 57 eyes from 47 glaucoma and glaucoma-suspect patients (age 67.6±8.0 yrs) with “complex” ERMs seen on ssOCT wide field scans (Topcon, Japan) and at least 2 scans > 6 months apart. Complex ERMs, which were defined as a hyper-reflective layer overlying the internal limiting membrane (ILM) with a gap separating it from retinal nerve fiber layer (RNFL), are seen as dark regions on en-face images obtained by averaging the reflective intensity of a 52 μm-thick slab below the ILM/ERM layer (Figs. 1, 2). [1, 2] Changes in ERMs were assessed by comparing en-face images and confirming with b-scans (Fig. 1). ERMs were classified as “progressing” if there was a increase in ERM area on en-face images or significant morphological changes (e.g., a new macular hole) on b-scans; as “regressing” if there was a decrease in ERM area on en-face images or ERM disappearance on b-scans; and “stable” if otherwise. Foveal thickness (FT) was measured, and Snellen visual acuity (VA) and risk factors for secondary ERMs were obtained by chart review. Chart history and VA was not available for 1 eye (stable), which was excluded from these analyses.

Results : As seen on en-face images and b-scans, 15 eyes (26.3%; follow-up: 18.3 to 51.0 mos) showed progressing ERMs (e.g., Fig. 1A, B); 7 eyes (12.3%; follow-up: 21.3 to 36.4 mos) showed regressing ERMs (e.g., Fig. 1C, D); and 35 eyes (61.4%; follow-up: 6.0 to 55.2 mos) were stable (e.g. Fig. 2). Mean changes in FT were 50.1±44.9 μm for progressing, 1.6±6.0 μm for regressing, and 0.3±13.7 μm for stable (one way ANOVA p <10-6). Mean changes in VA (converted to logMAR) were 0.04±0.10 (progressing), -0.03±0.11 (regressing), and 0.00±0.12 (stable) logMAR (not significant, one way ANOVA p = 0.35). 17 eyes (6 progressing, 1 regressing, 10 stable) had risk factors for secondary ERM, including uveitis, retinal detachment, and surgery (e.g. cataract surgery, trabeculectomy, vitrectomy).

Conclusions : The ERMs in the majority (61%) of eyes were stable over 6 to 55 months of follow-up. Changes, which could occur over intervals as short as 6 months, included increasing/decreasing ERM size, changes in ERM/RNFL attachment, and associated retinal defects such as macular holes. 1. Hood et al. IOVS (2016) 2. De Cuir et al. IOVS (2014)

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×