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TAI-CHI LIN, Yueqiao Qu, Youmin He, Xuejun Qian, Zhongping Chen, Qifa Zhou, Mark S. Humayun; High Resolution Optical Coherence Elastography of Retina under Prosthetic Electrode. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5835.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effect of prosthetic electrode on retinal biomechanical properties using acoustic radiation force optical coherence elastography (ARF-OCE)
A multielectrode array (MEA) was first implanted in each vitrectomized cadaveric pig eye, and then one retinal tack (medical grade titanium alloy, Ti 6AI 4V ELI; Second Sight Medical Products, Inc) was used to fix the electrode onto the retina. In this study, both qualitative and quantitative methods were used to track the changing elastic properties of the retinal tissue. The retina was excited by a 4.5 MHz ring-shaped ultrasonic transducer and its deformation was tracked by an 890-nm spectral domain optical coherence tomography system. The measured axial and lateral resolutions of the system were 3 and 27 µm respectively, and the imaging speed was 50k A-lines/s
Attenuated ARF through the electrode/polyimide and boundary conditions were observed, which made distinguishing the absolute elasticity of the retinal tissue layers and electrode difficult. OCE was able to separate the speed of propagation (used to reconstruct the absolute Young’s modulus) on the metal electrode and the retina. The results showed that the retina underneath the electrode (1.9 kPa) was softer than the other parts of the retina without the electrode (7 kPa). However, due to the effect of a stiff electrode (13.9 kPa) on top, the retinal layers gradient cannot be accounted for
OCE is a promising noninvasive imaging modality with high sensitivity (nanometer scale) and spatial resolution. In this study, we demonstrated the ability of OCE to distinguish retinal elastic properties with or without an implanted MEA. Further experiments will be done to obtain cumulative averaged data
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
OCE imaging of retinal elastic properties with or without an implanted MEA
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