Investigative Ophthalmology & Visual Science Cover Image for Volume 59, Issue 9
July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
High Resolution Optical Coherence Elastography of Retina under Prosthetic Electrode
TAI-CHI LIN; Yueqiao Qu; Youmin He; Xuejun Qian; Zhongping Chen; Qifa Zhou; Mark S. Humayun
Author Affiliations & Notes
  • TAI-CHI LIN
    Department of Ophthalmology , USC Roski Eye Institute, Los Angeles, California, United States
  • Yueqiao Qu
    Department of Biomedical Engineering, Beckman Laser Institute, University of California, Irvine, Irvine, California, United States
  • Youmin He
    Department of Biomedical Engineering, Beckman Laser Institute, University of California, Irvine, Irvine, California, United States
  • Xuejun Qian
    Department of Biomedical Engineering and Ophthalmology , University of Southern California, Los Angeles, California, United States
  • Zhongping Chen
    Department of Biomedical Engineering, Beckman Laser Institute, University of California, Irvine, Irvine, California, United States
  • Qifa Zhou
    Department of Biomedical Engineering and Ophthalmology , University of Southern California, Los Angeles, California, United States
  • Mark S. Humayun
    Department of Ophthalmology , USC Roski Eye Institute, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   TAI-CHI LIN, None; Yueqiao Qu, None; Youmin He, None; Xuejun Qian, None; Zhongping Chen, OCT Medical Imaging (I), OCT Medical Imaging (C), OCT Medical Imaging (P), OCT Medical Imaging (S); Qifa Zhou, Newway Technology Inc. (C); Mark Humayun, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5835. doi:
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      TAI-CHI LIN, Yueqiao Qu, Youmin He, Xuejun Qian, Zhongping Chen, Qifa Zhou, Mark S. Humayun; High Resolution Optical Coherence Elastography of Retina under Prosthetic Electrode. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5835.

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Abstract

Purpose : To evaluate the effect of prosthetic electrode on retinal biomechanical properties using acoustic radiation force optical coherence elastography (ARF-OCE)

Methods : A multielectrode array (MEA) was first implanted in each vitrectomized cadaveric pig eye, and then one retinal tack (medical grade titanium alloy, Ti 6AI 4V ELI; Second Sight Medical Products, Inc) was used to fix the electrode onto the retina. In this study, both qualitative and quantitative methods were used to track the changing elastic properties of the retinal tissue. The retina was excited by a 4.5 MHz ring-shaped ultrasonic transducer and its deformation was tracked by an 890-nm spectral domain optical coherence tomography system. The measured axial and lateral resolutions of the system were 3 and 27 µm respectively, and the imaging speed was 50k A-lines/s

Results : Attenuated ARF through the electrode/polyimide and boundary conditions were observed, which made distinguishing the absolute elasticity of the retinal tissue layers and electrode difficult. OCE was able to separate the speed of propagation (used to reconstruct the absolute Young’s modulus) on the metal electrode and the retina. The results showed that the retina underneath the electrode (1.9 kPa) was softer than the other parts of the retina without the electrode (7 kPa). However, due to the effect of a stiff electrode (13.9 kPa) on top, the retinal layers gradient cannot be accounted for

Conclusions : OCE is a promising noninvasive imaging modality with high sensitivity (nanometer scale) and spatial resolution. In this study, we demonstrated the ability of OCE to distinguish retinal elastic properties with or without an implanted MEA. Further experiments will be done to obtain cumulative averaged data

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

OCE imaging of retinal elastic properties with or without an implanted MEA
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OCE imaging of retinal elastic properties with or without an implanted MEA

OCE imaging of retinal elastic properties with or without an implanted MEA

OCE imaging of retinal elastic properties with or without an implanted MEA
View OriginalDownload Slide

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2025 Association for Research in Vision and Ophthalmology.
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