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KAI GAO, Fei Li, Ye Yuan, Rouxi Zhou, Yi Sun, Xiulan Zhang; Effect of Prostaglandin Analogues on Anterior Choroid Thickness in Untreated Primary Open Angle Glaucoma: An SS-OCT Study. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5911.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the effect of prostaglandin analogues (PGAs) on anterior choroid thickness in previously untreated patients with primary open-angle glaucoma (POAG), using swept-source optical coherence tomography (SS-OCT).
Thirteen eyes of thirteen newly diagnosed and previously untreated patients aged 26-54 years with POAG were treated with PGAs. The thickness of the choroid at a distance of 4 mm from the root of the iris was defined as anterior choroid thickness (ACT) using SS-OCT. At baseline examination, ACT of nasal and temporal quadrants, intraocular pressure (IOP), spherical equivalent (SE), axial length (AL), and visual field (VF) results were recorded. After a treatment period of 1-month and 3-months with PGAs, all procedures were repeated. The ACT changes before and after treatment were analyzed using two-tailed, paired t tests. Univariate and multivariate linear regression was used to determine the relationship between the changes in ACT, IOP, and other biometric parameters.
Compared to baseline IOP (20.8 ± 3.3 mmHg; mean ± standard deviation), IOP was significantly reduced after treatment with PGAs at month 1 (14.7 ± 2.6 mmHg; P < 0.01) and month 3 (14.8 ± 3.6 mmHg; P < 0.01). There was no significant difference in ACT after treatment for one month (baseline: 0.154 ± 0.02 mm; month 1: 0.144 ± 0.01 mm; P = 0.158). But the ACT was significantly increased after treatment for three months compared to baseline ACT (baseline: 0.154 ± 0.02 mm; month 3: 0.18 ± 0.03 mm; P < 0.01). There was no significant association between the changes of ACT and all other biometric parameters (P > 0.05).
This is the first study to investigate the effect of PGAs on ACT in previously untreated POAG patients. Our results suggest that the PGAs could significantly reduce IOP and increase ACT in POAG patients, which may be associated with changes of anterior uveal vasculature after treatment of PGAs. Further researches are needed to investigate the possible mechanism of this findings.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
Figure. SS-OCT image showing the measurement of ACT. We first determined the root of the iris. Through the root of the iris, we draw a line parallel with the inner surface of sclera. ACT is the thickness of the anterior choroid at a distance of 4 mm from the root of the iris.
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