July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Comparing endoscopic cyclophotocoagulation-plus (ECP-Plus) with anterior ECP for the treatment of refractory glaucoma
Author Affiliations & Notes
  • Jessica Minjy Kang
    Ophthalmology, UCSF, San Francisco, California, United States
  • Max Feinstein
    Ophthalmology, UCSF, San Francisco, California, United States
  • Jun Hui Lee
    Ophthalmology, UCSF, San Francisco, California, United States
  • Behzad Amoozgar
    Ophthalmology, UCSF, San Francisco, California, United States
  • Kelsey Liu
    Ophthalmology, UCSF, San Francisco, California, United States
  • Jay M Stewart
    Ophthalmology, UCSF, San Francisco, California, United States
  • Gabriel Lazcano-Gomez
    Asociación para Evitar la Ceguera en México, Mexico City, Mexico
  • Travis Porco
    Ophthalmology, UCSF, San Francisco, California, United States
  • Ying Han
    Ophthalmology, UCSF, San Francisco, California, United States
  • Footnotes
    Commercial Relationships   Jessica Kang, None; Max Feinstein, None; Jun Hui Lee, None; Behzad Amoozgar, None; Kelsey Liu, None; Jay Stewart, None; Gabriel Lazcano-Gomez, None; Travis Porco, None; Ying Han, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 6102. doi:
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    • Get Citation

      Jessica Minjy Kang, Max Feinstein, Jun Hui Lee, Behzad Amoozgar, Kelsey Liu, Jay M Stewart, Gabriel Lazcano-Gomez, Travis Porco, Ying Han; Comparing endoscopic cyclophotocoagulation-plus (ECP-Plus) with anterior ECP for the treatment of refractory glaucoma. Invest. Ophthalmol. Vis. Sci. 2018;59(9):6102.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the efficacy and safety of a new endocyclophotocoagulation (ECP) procedure, ECP-plus, and compare this with anterior ECP for the treatment of refractory glaucoma.

Methods : This was a retrospective case series performed at an academic institution. A total of 58 eyes from 54 patients who underwent either anterior ECP or ECP-plus between 2011 and 2016 were included in the study. Twenty-five eyes were treated with ECP-plus and 33 eyes were treated with anterior ECP with two years of follow up. The primary outcome of the study was intraocular pressure (IOP). Secondary outcomes were best corrected visual acuity (BCVA), number of glaucoma medications required, success rate of the procedure, and post-procedural complications. Outcome measurements were compared between the two cohorts using linear mixed regression, adjusting for preoperative metrics such as degrees of the ciliary body treated, and combined ECP procedures with cataract surgery.

Results : Eyes that received ECP-plus had lower IOP (p = 0.023), used fewer number of glaucoma medications (p = 0.003), and achieved a higher success rate at two years postoperatively (p < 0.001). Additionally, the decrease in IOP between preoperative and last follow-up visits was significantly greater in the ECP-plus group compared to the anterior ECP group (-14.3 mmHg (52% reduction) vs. -5.2 mmHg (24% reduction), p = 0.001). The difference in complication rates between the ECP-plus and anterior ECP groups were not statstically significant (p = 0.561), and both groups maintained stable BCVA throughout the study.

Conclusions : Compared to anterior ECP, ECP-plus has a similar safety profile and may offer superior IOP control for the management of refractory glaucoma.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Average intraocular pressure (a), number of glaucoma medications (b), and BCVA (c) of anterior ECP and ECP-plus patients over the course of two years. Error bars are SEM. Empty circle represents anterior ECP and solid circle represents ECP-Plus.

Average intraocular pressure (a), number of glaucoma medications (b), and BCVA (c) of anterior ECP and ECP-plus patients over the course of two years. Error bars are SEM. Empty circle represents anterior ECP and solid circle represents ECP-Plus.

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