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Fatimah Alhammad, DEEPAK P EDWARD, Azza Maktabi, Rajiv Khandekar, Osama Alsheikh; Does Cosmetic Related Lacrimal Sac Pigmentation Play a Role in Chronic Dacryocystitis?. Invest. Ophthalmol. Vis. Sci. 2018;59(9):100.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the incidence of lacrimal sac pigmentation (LSP) in chronic dacryocystitis (CD) biopsies and the role of LSP in the pathogenesis of CD.
A histopathological study was performed of lacrimal sac tissue to evaluate the absence or presence of LSP and related inflammation; and its association with demographics, clinical features, postoperative complications and recurrence of CD. P<0.05 was considered statistically significant.
Of the 177 CD specimens, black pigment aggregates were noted in the sac stroma of 61 lacrimalsac specimens (34.5%; 95% Confidence Interval: 27.5 – 47.5). LSP was significantly more common in females (P<0.001). The age, residence, past ailments and laterality were not associated with LSP. Dry eye was more common with LSP (P = 0.004). Other presenting symptoms, postoperative complications and recurrence were not significantly associated with LSP. The stromal pigment was mostly extracellular or in macrophages. Energy dispersive spectroscopy determined that Carbon and Sulfur were the main elements in the pigment aggregates.
LSP appears to be an incidental finding in CD, and is unlikely to play a role in pathogenesis. Dry eyes were significantly associated with LSP.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
Figure 1: Microphotograph showing biopsy of the wall of stroma underlying the lacrimal sac epithelium. Note the dense fibrous stroma with scattered pockets of infiltrating lymphocytes and plasma cells. Free jet black pigment (arrows) and pigment-laden macrophages (arrows) are noted in the stroma (hematoxylin and eosin;40 x)
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