July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Swept-source optical coherence tomography with multiple B-scan averaging in the management of anterior scleral inflammation
Author Affiliations & Notes
  • Maite Sainz De La Maza
    Clinic Institute of Ophthalmology, Hospital Clinic of Barcelona, BARCELONA, Spain
  • Mireia Hereu
    Clinic Institute of Ophthalmology, Hospital Clinic of Barcelona, BARCELONA, Spain
  • Monica Hernandez
    Clinic Institute of Ophthalmology, Hospital Clinic of Barcelona, BARCELONA, Spain
  • Marina Mesquida
    IDIBAPS, Barcelona, Spain
  • Victor Llorenç
    Clinic Institute of Ophthalmology, Hospital Clinic of Barcelona, BARCELONA, Spain
  • Alfredo Adan Civera
    Clinic Institute of Ophthalmology, Hospital Clinic of Barcelona, BARCELONA, Spain
  • Javier Zarranz-Ventura
    Clinic Institute of Ophthalmology, Hospital Clinic of Barcelona, BARCELONA, Spain
  • Footnotes
    Commercial Relationships   Maite Sainz De La Maza, None; Mireia Hereu, None; Monica Hernandez, None; Marina Mesquida, None; Victor Llorenç, None; Alfredo Adan Civera, None; Javier Zarranz-Ventura, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1095. doi:
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      Maite Sainz De La Maza, Mireia Hereu, Monica Hernandez, Marina Mesquida, Victor Llorenç, Alfredo Adan Civera, Javier Zarranz-Ventura; Swept-source optical coherence tomography with multiple B-scan averaging in the management of anterior scleral inflammation. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1095.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the scleral changes observed in patients with active and inactive anterior scleritis with a swept-source optical coherence tomography device (SS-OCT, DRI Triton, Topcon, Japan).

Methods : Single centre consecutive case series of unilateral anterior scleritis. SS-OCT images were acquired in patients with active scleritis and followed up until remission with sequential scans. Healthy fellow eye was used as a control. Images were quantitatively assessed using the caliper incorporated in the device software. Analysis included measurement of thickness of total sclera, conjunctival epithelium, conjunctival stroma/episclera, and scleral stroma in the mid point between the sclerocorneal limbus and the rectus muscle insertion rim (Tillaux spiral) in active and inactive scleritis. Thickness measurements were also compared between diffuse and nodular scleritis for each layer.

Results : Thirty five active scleritis eyes were included in the study. Of them, 75% had diffuse scleritis, 14% nodular scleritis, and 14% necrotizing scleritis. Mean total scleral thickness was significantly higher during active phase compared to remission phase (887.9±216.0 mm vs 676±98.50 mm, p<0.001). Conjunctival epithelium and scleral stroma were not significantly thicker in eyes with active scleritis than in eyes with inactive scleritis (55.8±27 mm vs 50.3±13 mm, p=0.56 and 360.4±113.2 mm vs 323±96 mm, p=0.23, respectively). Conjunctival stroma/episclera was significantly thicker in eyes with active scleritis than in eyes with inactive scleritis (440.7±154 mm vs 277±61.2 mm, p<0.001). No significant differences were observed between the inactive phase and the normal fellow eye. Only conjunctival stroma/episcleral thickness was significantly higher in nodular scleritis than in diffuse scleritis.

Conclusions : SS-OCT DRI Triton can be employed to obtain direct images of the anterior sclera, allowing adequate identification of conjunctival epithelium, conjunctival stroma/episclera, and scleral stroma layers that may be useful in the assessment of the inflammatory status in scleritis. Eyes with active scleritis have inflammation within the conjunctival stroma/episclera layer more actively than within the scleral stroma layer. Nodular scleritis have thicker conjunctival stroma/episclera layer than diffuse scleritis. These findings may have therapeutic implications.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

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