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Jasmine Masuzaki Wong, Fabio Antonio Del Picchia de Araujo Nogueira, Richard Y Hida, Davi Chen Wu, Pedro Augusto de Andrade Poletto, Adamo Lui Netto; Factors that impact on the quality of donor corneas: 9 year-retrospective analysis. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1301.
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© ARVO (1962-2015); The Authors (2016-present)
The purpose is to analyze the factors that could have impact on the quality of the donated corneas for the past 9 years.
A cross sectional retrospective analysis was performed using the records of 1945 donors (56.3% males, 48.61 ± 17.42 years old) of Santa Casa de São Paulo Eye Bank from July/2008 to June/2017. The following items were evaluated for analysis: death/preservation interval, age, cause of death, and whether was a multiple organs donor or not. For the analysis of the causes of death, all data were divided in 4 groups: Cardiovascular diseases; Consumptive diseases; Traumatic deaths and others. We considered only the best cornea in quality for each donor (optical or tectonic graft). Chi Square; Mann-Whitney and Kruskal-Wallis were applied with level of significance of 0.5.
Among the cause of deaths, cardiovascular disease was the most common (50.49%), followed by traumatic deaths (26.58%). The corneas from traumatic deaths had better quality compared to the corneas donated from other non-traumatic causes (p<0.01). Most of the corneas were from multiple organ donors (67.81%) and the corneas from multiple organ donors showed better quality (p<0.01). The mean death/preservation interval was 165.35 ± 111.77 minutes for optical grafts and 195.76 ± 136.14 minutes for tectonic grafts (p<0.01). Donor corneas aged 60 years old or more had worse quality, but was responsible for a quarter of the corneas acquired for transplantation.
Shorter death/preservation interval, multiple organ donors, traumatic deaths, and donors less than 60 years old seem to impact directly in better quality of donor corneas for transplantation.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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