July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Total retinal detachments due to retinoblastoma: Outcomes following intra-arterial chemotherapy/ophthalmic artery chemosurgery
Author Affiliations & Notes
  • Megan Rowlands
    Medicine, The Memorial Sloan Kettering Cancer Center, New York City, New York, United States
  • Ijah Mondesire-Crump
    Surgery, The Memorial Sloan Kettering Cancer Center, New York City, New York, United States
  • Ariana Levin
    Surgery, The Memorial Sloan Kettering Cancer Center, New York City, New York, United States
  • Audrey Mauguen
    Epidemiology and Biostatistics, The Memorial Sloan Kettering Cancer Center, New York City, New York, United States
  • Jasmine H Francis
    Surgery, The Memorial Sloan Kettering Cancer Center, New York City, New York, United States
    Ophthalmology, Weill Cornell Medical College, New York City, New York, United States
  • Ira Dunkel
    Pediatrics, Weill Cornell Medical College, New York City, New York, United States
    Pediatrics, The Memorial Sloan Kettering Cancer Center, New York City, New York, United States
  • Scott E Brodie
    Ophthalmology, Mt. Sinai School of Medicine, New York City, New York, United States
  • Yves Pierre Gobin
    Surgery, The Memorial Sloan Kettering Cancer Center, New York City, New York, United States
    Neurosurgery, Weill Cornell Medical College, New York City, New York, United States
  • David H Abramson
    Surgery, The Memorial Sloan Kettering Cancer Center, New York City, New York, United States
    Ophthalmology, Weill Cornell Medical College, New York City, New York, United States
  • Footnotes
    Commercial Relationships   Megan Rowlands, None; Ijah Mondesire-Crump, None; Ariana Levin, None; Audrey Mauguen, None; Jasmine Francis, None; Ira Dunkel, None; Scott Brodie, None; Yves Gobin, None; David Abramson, None
  • Footnotes
    Support  Fund for Ophthalmic Knowledge, Inc
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1644. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Megan Rowlands, Ijah Mondesire-Crump, Ariana Levin, Audrey Mauguen, Jasmine H Francis, Ira Dunkel, Scott E Brodie, Yves Pierre Gobin, David H Abramson; Total retinal detachments due to retinoblastoma: Outcomes following intra-arterial chemotherapy/ophthalmic artery chemosurgery. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1644.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To report on the rate and timing of retinal reattachment and outcomes for retinoblastoma children who have total retinal detachments at presentation to our center and were treated with intra-arterial chemotherapy (ophthalmic artery chemosurgery, OAC).

Methods : Single-center retrospective review of retinoblastoma patients who presented with total retinal detachments and were subsequently treated with OAC at MSKCC between May 2006 and July 2016. Endpoints were retinal detachment resolution, visual function, ERG amplitude, ocular survival, and patient survival from metastases.

Results : 95 eyes of 92 retinoblastoma patients were included. Using a survival multistate model, by 36 months of follow-up, there was a 56% cumulative probability of complete retinal reattachment and a 78% probability of partial reattachment. 22% of eyes that completely reattached received only OAC without any prior or adjuvant treatments. Eyes that completely reattached were significantly more likely to have been diagnosed at a younger age (p<0.0001) and to have greater initial ERG values (p=0.01). At final follow-up, 15% of eyes had gained at least 25 mV of ERG activity, and 7.5% had achieved hand motion vision or better, including one to 20/60. 15% of eyes were enucleated. No patient died from metastatic disease.

Conclusions : OAC can successfully treat previously considered “non-salvageable” retinoblastoma eyes with total retinal detachments, promote retinal reattachment in the majority of eyes, and preserve ocular and patient survival.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×