July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Quantification of Synchronized Lens and Pupil Dynamics During Accommodation
Author Affiliations & Notes
  • Yu-Cherng Chang
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Florence Cabot
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Siobhan Williams
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Giovanni Gregori
    Quantitative Imaging Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Marco Ruggeri
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Arthur Ho
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
  • Sonia H Yoo
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Jean-Marie A Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Brien Holden Vision Institute and Vision Cooperative Research Centre, Sydney, New South Wales, Australia
  • Fabrice Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Footnotes
    Commercial Relationships   Yu-Cherng Chang, None; Florence Cabot, None; Siobhan Williams, None; Giovanni Gregori, None; Marco Ruggeri, US Patent 8,425,037 (P); Arthur Ho, None; Sonia Yoo, None; Jean-Marie Parel, US Patent 8,425,037 (P); Fabrice Manns, US Patent 8,425,037 (P)
  • Footnotes
    Support  National Eye Institute Grants 1F30EY027162, 2R01EY14225, P30EY14801 (Center Grant); Florida Lions Eye Bank; Drs KR Olsen and ME Hildebrandt; Drs R Urs and A Furtado; the Henri and Flore Lesieur Foundation (JMP); an unrestricted grant from Research to Prevent Blindness; and the Australian Federal Government Cooperative Research Centre Scheme through the Vision Cooperative Research Centre.
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1949. doi:
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    • Get Citation

      Yu-Cherng Chang, Florence Cabot, Siobhan Williams, Giovanni Gregori, Marco Ruggeri, Arthur Ho, Sonia H Yoo, Jean-Marie A Parel, Fabrice Manns; Quantification of Synchronized Lens and Pupil Dynamics During Accommodation. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1949.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Presbyopia is driven by a loss of lens responsiveness, but the effect of lens changes may be diminished by adaptive changes such as increased "pseudoaccommodation" through changes in pupil size. We explore the role of the pupil by quantifying lens and pupil behavior during accommodation in individuals from a young to pre-presbyopic population.

Methods : The left eyes from 9 subjects were imaged during responses to step accommodation stimuli using a custom-built extended depth OCT system (Ruggeri et al, Biomed Opt Express 3:1506-1520; 2012) (12,500 A-lines/s, 8 µm axial resolution, 13.5 mm imaging depth). 7 subjects (22-39 y/o) were imaged at stimuli of 2 and 4D and 2 (45 and 46 y/o) at 2D only. Cross-sectional images were acquired at 400 A-lines/frame and 13 frames/s producing dynamic datasets of the accommodative response of the anterior segment from anterior cornea to posterior lens. Lens thickness (LT) and pupil diameter (PD) were determined for each frame through automatic segmentation (Figure 1). Changes in LT and PD were determined as the difference between the average LT and PD for the last and first 10 images, normalized by stimulus, and then averaged across stimulus levels. To quantify the relation between the time course of LT and PD change in an individual, the time-points at which PD and LT reached their steady state values, defined as the values of PD and LT averaged over the last 10 images, respectively, were calculated, and the difference in time between the two time-points (Δt) was determined.

Results : As shown in Figure 2, LT change during accommodation did not differ significantly with age (p = 0.32) with a mean LT change/D of 0.055 mm/D, whereas the magnitude of PD change during accommodation increased with age (p = 0.01; PD change/D = -0.018 mm * Age + 0.220 mm). Δt appeared to increase with age in 2D trials, but the relationship did not reach significance (p = 0.10).

Conclusions : The age-related increase in PD change manifested in a longer response of the pupil relative to the lens with increasing age, suggesting the pupil may be involved in compensating for the loss of lens accommodation with age.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

 

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