Reproducibility of AngioAnalytics Measurements of OCTA Retina Scans in Normal, Glaucoma and Diabetic Retinopathy Eyes

Abstract

Purpose : To evaluate the reproducibility of Superficial and Deep Vascular Complex vessel density (SVC-VD and DVC-VD) of 6mm HD Angio Retina scans, and foveal avascular zone (FAZ) parameters of 3mm Angio Retina scans (Picture 1) in 3 patient groups.

Methods : Following IRB approval, up to 3 repeats of 3mm and 6mm HD Angio Retina scans were acquired on 3 different XR Avanti with AngioVue® devices (up to 9 scans per scan type per eye). One eye per patient for 15 normal (N), 16 glaucoma (G), and 12 diabetic retinopathy (DR) eyes were included. N group was distributed by age (range 19-84 years old); G group included early to advanced disease (visual field MD range -0.32 to -25.79 dB); DR eyes with DME (9 eye) and without (3 eyes), and various DR severity were included.

SVC-VD and DVC-VD was evaluated for Whole Image (WI) and Superior and Inferior Hemifield (WI-SHemi and WI-IHemi) of 6mm HD Angio Retina scan. FAZ parameters included FAZ area (FAZ-A) and vessel density within 300µm width peri-FAZ ring (FD) of the 3mm Angio Retina scan (Picture1).

For a given study parameter, the mean measurement value and standard deviation value of the 9 scans was computed for each study eye. Then the average of the mean measurement values and standard deviation values among the subjects for each study group were computed. Standard two-sample t-test was performed to test the statistical significance of the difference between a patient group (G or DR) and the normal (N) group (Table 1B).

Results : Reproducibility of all evaluated parameters is shown in Table 1A.
Statistically significant difference of means was found for SVC and DVC vessel density in G vs N, and in DR vs N group, without significant difference in reproducibility except for SVC-VD of the DR vs N group (Table 1B).
FAZ parameters reproducibility was not significantly different between G vs N, and DR vs N, however FD difference of the means was significant in DR vs N group (Table 1B).

Conclusions : In our sample population, all evaluated parameters were highly reproducible in three study groups.
SVC and DVC vessel density is lower in DR and G than in N group. Foveal vessel density is lower in DR than in N group, and similar in G vs N group. FAZ area is not significantly different in DR and G vs N group.
Reproducibility of vessel density and FAZ measurements is similar in N, G and DR groups, except variability is lower for SVC-VD in DR group.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Picture 1