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Matthias Salas, Marco Augustin, Franz Felberer, Laurin Gabriel Ginner, Andreas Wartak, Rainer Leitgeb, Xavier Levecq, Adrian Reumüller, Andreas Pollreisz, Ursula Schmidt-Erfurth, Wolfgang Drexler, Michael Pircher; Compact retinal optical coherence tomography instrument at 1060nm for large field of view imaging including an optical zoom in option using adaptive optics. Invest. Ophthalmol. Vis. Sci. 2018;59(9):297.
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© ARVO (1962-2015); The Authors (2016-present)
To introduce a compact optical coherence tomography (OCT) instrument at 1060nm with switchable imaging modes. To investigate the performance of the system in healthy and diseased eyes and to evaluate structural and angiographic information.
The compact instrument combines two imaging modes. The first imaging mode supports a field of view (FoV) of up to 45ox30o with standard OCT resolution. By switching mirrors in the sample and reference arm, the system can be changed into an adaptive optics (AO) OCT imaging mode with a FoV of 3ox2.8o and ~3µm lateral resolution. This imaging mode allows for an optical zoom into ROIs such as transition zones between healthy and diseased retinal with cellular resolution. The OCT engine is based on an akinetic swept laser source at 1060nm with a sweep range of 60nm and provides an A-scan rate of 200 kHz. The high phase stability of the light source enables the use of various methods for angiographic data evaluation. Structural and angiographic information are retrieved with both imaging modalities in healthy eyes and diseased eyes with age related macular degeneration.
Figure A shows a representative fundus image recorded with the large FoV mode generated by depth integrating over the entire retina. The angiographic data reveals the capillary structure of the inner retina (three vasculature beds) and choriocapillaries (cf. Fig.B). High transverse resolution provided by the AO-mode enables the visualization of photoreceptors (cf. Fig.C). A comparison between large FoV mode and AO mode can be seen in Figs. D and E. Due to the higher resolution of the AO mode, the retinal vasculature can be better visualized. An angiographic image of choriocapillaris recorded with the AO mode is shown in Fig.F. Finally, Fig.G shows the vasculature in a patient with geographic atrophy.
The performance of the instrument in healthy volunteers and patients with various diseases is excellent particularly in regard to its multimodal capability. The large FoV mode provides similar structural information of the retina as comparable state of the art instruments. In addition, the AO mode allows visualization of cellular structures such as cone photoreceptors. Direct comparison of the same retinal area recorded with both imaging modes provides information on the correct interpretation of large FoV images.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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