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JUAN ESTEBAN UNIGARRO MARTINEZ, SOFIA VIDAL, SERGIO ARRASCUE LIMO, Carlos A. Abdala; Factors Associated with the finding of choroidal neovascularization by Swept-Source Optical Coherence Tomography Angiography in Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3159.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate factors associated with the Choroidal neovascularization (CNV) exposed by swept-source optical coherence tomography angiography (SS-OCTA) in patients with central serous chorioretinopathy (CSC)
Observational cross-sectional study that included 20 eyes of 16 patients with CSC diagnosis. The participants were recruited prospectively, to perform an SS-OCTA, using 6x6 images with Triton SS-OCT, centered on the macula in order to evaluate the presence of CNV. Clinical findings, SS-OCT and SS-OCTA data were analyzed. Variables were: age, disease time, best correct visual acuity at the time of diagnosis (BCVA), number of treatment interventions (NTI), ETDRS macular central thickness (ETDRS-CT), cubic macular volume (CMV), central choroidal thickness (CCT), neurosensorial epithelium detachment height (NSED-H), neurosensorial epithelium detachment area (NSED-A), number of recurrences (NR) and submacular choroidal fluid area (SCFA). Groups were made for data correlation: CNV vs No CNV, Activity vs Inactivity of the disease and Acute vs Chronic presentation; a subgroup with active disease was analyzed comparing CNV vs No CNV. SPSS V. 23 and R V.3.2.2 statistical package and U Mann-Whitney-Wilcoxon non-parametric tests with IC 95% and statistical significance 5% were use for statistical analysis
3 eyes (15%) showed an imagine of CNV; the mean age of participants was 50.2 (40–70 years); Box-Plot Graphic shows presence of extreme ages and grouping data to elderly ages in CNV group; two variables had significat statical association with presence of CNV in active subgroup: NR (95%CI; p=0.02) and NTI (95%CI; p=0.02), the main NR in the active subgroup was 1,66 times for CNV vs 0,47 times for No CNV; the main NTI was 4,5 times for CNV vs 2,1 times for No CNV. No statistical significance was shown for any other variable, although the other variables could probably have statistical significance with a greater number of population
A significant association was observed between the NR as well as NTI and presence of CNV, which suggests that we should suspect the presence of CNV in patients with refractory response to different treatments and who show several recurrence over time. The presence of NVC was observed more frequently in patients with extreme ages and a tendency to elderly ages
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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