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Pablo Sanz Diez, Li-Hua Yang, Wen-Long Xu, Yun-Ning Xiong, Mei-Xia Lu, Arne Ohlendorf, Siegfried Wahl; Growth curves of myopia related parameters to clinically monitor the refractive development in Chinese schoolchildren.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3386. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To produce a clinical model for the prediction of myopia development based on the creation of percentile curves of axial length and other related parameters.
Data of 12,554 children were collected by the Wuhan Center for Adolescent Poor Vision Prevention & Control. The following parameters were obtained under cycloplegia (four times 0.5% cyclopentolate): axial length (AL), corneal curvature (CR), anterior chamber depth (ACD), lens thickness (LT) and spherical equivalent refractive error (SE). The study cohort consisted of 6,054 girls (mean SE: -0.93±1.85D, aged 6-15 years) and 6,500 boys (aged 6-15 years, mean SE: -0.88 ±1.83D). Percentile curves were calculated for both gender groups and four age groups (6, 9, 12 and 15 year), while only data from the right eyes were used for analysis. Myopia was defined as SE ≤-0.50D, emmetropia as -0.50<SE<+2.00D, and hyperopia as SE ≥+2.00D.
The mean values of the SE, the AL, the CR and the AL/CR ratio depending on the gender (table 1), while it was observed that the SE was an age-dependent variable in both females and males (ANOVA, LSD post-hoc, F=234.216 p=0.000, F=228.614 p=0.000, respectively), but not gender-dependent (ANOVA, F=2.184 p=0.139). On average, the females in each age group had significantly shorter AL, steeper CR, and lower AL/CR ratios compared to the males in their respective age groups (p<0.01). There was a positive correlation between SE and CR (Pearson Correlation = 0.027; p = 0.002), while there was also a negative correlation between SE and AL (Pearson Correlation = -0.768; p = 0.000); and between SE and AL/CR ratio (Pearson Correlation = -0.872; p = 0.000). From 6 to 15 years of age, all of the percentiles showed a growth trend in AL and AL/CR ratio, except for the percentiles below the first quartile, which appear to stabilize after the age of 12. No statistical significant growth was observed for AL (p=0.234 for girls; p=0.343 for boys) and AL/CR ratio (p=0.360 for girls; p=0.594 for boys).
The data from current study allows us to observe the annual growth rates of several variables that are known to be linked to the development and progression of myopia in a group of Asian and these values can be taken as a clinical reference.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
Table 1. Mean values of AL, CR, AL/CR ratio and SE.
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