July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Conjunctival microvascular alterations in dry eye patients and their responses to anti-inflammation treatment
Author Affiliations & Notes
  • YUQING DENG
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States
    Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, Guangdong, China
  • Jianhua Wang
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States
  • Hong Jiang
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States
    Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Wan Chen
    Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, Guangdong, China
  • Jin Yuan
    Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, Guangdong, China
  • Footnotes
    Commercial Relationships   YUQING DENG, None; Jianhua Wang, None; Hong Jiang, None; Wan Chen, None; Jin Yuan, None
  • Footnotes
    Support  Grant/financial support: support by the National key research and development program to JY (2017YFC0112400) in Zhongshan Ophthalmic Centre, Sun Yat-sen University and by grants from the National Natural Science Foundation of China to JY (81670826).
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4902. doi:
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    • Get Citation

      YUQING DENG, Jianhua Wang, Hong Jiang, Wan Chen, Jin Yuan; Conjunctival microvascular alterations in dry eye patients and their responses to anti-inflammation treatment. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4902.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : This study aimed to characterize the microvasculature and microcirculation of the bulbar conjunctiva in patients with dry eye disease (DED) as well as their responses to anti-inflammation treatment.

Methods : Twenty-five patients with DED (20 females and 5 males, aged 48.4 ± 16.8 years, mean ± standard deviation), 25 age- and gender-matched healthy subjects (20 females and 5 males, aged 49.1±16.7 years) were recruited and filled out the ocular surface disease index (OSDI). The conjunctival blood flow velocities (BFVs) and vessel diameters were measured using Functional Slit-lamp Biomicroscopy (FSLB). The repeat measurements were performed in DED group at 30 and 60 days during anti-inflammation treatment. Other clinical measurements were also administrated in the follow-up of DED group, including the noninvasive tear-film break-up times (NI-fBUT and NI-avBUT, respectively), the hyperemia index (HI) of the bulbar conjunctiva, OSDI, Schirmer I test (ST) scores and corneal fluorescein staining scores.

Results : The bulbar BFV, vessel diameter and OSDI in DED group were significantly higher than control group, (P < 0.05 respectively). 60 days after anti-inflammatory therapy, significant decreases in BFV, HI, vessel diameter, OSDI, and corneal fluorescein staining score were found (all P < 0.05) (Figure 1). Moreover, significant increases in NI-fBUT and NI-avBUT were observed. The corneal staining score was related to BFV (r = 0.48, P < 0 .0001) and HI (r = 0.30,P =0.009). HI was also related to BFV (r = 0.28, P = 0.014).

Conclusions : Increased bulbar BFV and larger vessel diameter were found in bulbar conjunctiva of DED patients, which may indicate underlying chronic inflammation. The decreases in BFV, vessel diameter and HI may be useful in noninvasive efficacy evaluations of dry eye treatments.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Figure 1: Bulbar conjunctival microvascular, ocular symptoms and signs alterations in dry eye patients. Average BFV and vessel diameter were significantly higher in DED group than control (P < 0.001, A). Compared to the baseline values, BFV, vessel diameter and HI were decreased at 30 and 60 days during anti-inflammatory therapy (B). A typical case of a patient with Sjögren's syndrome and severe DED with recovery of the microvascular parameters and tear-film stability (C).The measurements at baseline and at 30 and 60 days after treatment are presented on the right.

Figure 1: Bulbar conjunctival microvascular, ocular symptoms and signs alterations in dry eye patients. Average BFV and vessel diameter were significantly higher in DED group than control (P < 0.001, A). Compared to the baseline values, BFV, vessel diameter and HI were decreased at 30 and 60 days during anti-inflammatory therapy (B). A typical case of a patient with Sjögren's syndrome and severe DED with recovery of the microvascular parameters and tear-film stability (C).The measurements at baseline and at 30 and 60 days after treatment are presented on the right.

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