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xavier proumen, Ann-Pascale guagnini, Paulina Bartoszek, Alexandra Kozyreff, Patrick De Potter; Single photodynamic therapy session for exudative circumscribed choroidal hemangiomas. Clinical series of 33 patients.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5591.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effectiveness of a single session of PDT for exudative circumscribed choroidal hemangiomas (CCH).
Prospective non comparative case series including 33 patients with symptomatic exudative CCH. Our protocol included a single session of PDT performed 2 minutes after IV bolus injection of verteporfin (6mg/m2) at 689nm with a light dose of 100J/cm2 (600mW/cm2 for 166 seconds).
The mean tumor thickness before PDT was 3,5 mm (range, 2.6-6 mm) and the mean largest TBD was 6.6 mm (range, 4,5-12mm). After a mean follow-up of 104 months (range, 12-170 months), all CCH (100%) showed regressed tumor thickness, resolution of subretinal fluid and no recurrent leakage. Visual improvement was documented in 25 eyes (76%,P<0.001) and a flat tumor scar in 25 eyes ( 76%, P<0.001). No other PDT session was needed.
This protocol with a single session of PDT offered a safe and effective option in treating symptomatic exudative CCH in terms of visual recovery, tumor thickness regression, and resolution of subretinal fluid with exudative recurrence.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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