Changes in the Density of Choroicapillary and Choroidal Thickness in Myopic Patients with Femtosecond Laser in Situ Keratomileusis

Abstract

Purpose : To investigate changes in density of choroicapillary (CCD) and choroidal thickness(CT) and the relationship between them in myopic patients accepted femtosecond laser in situ keratomileusis (Femto-LASIK).

Methods : 37 patients (65 eyes) with myopia and without other ophthalmic or systemic diseases who were eligible for Femto-LASIK surgery were enrolled. The CCD was measured in the Central 1-mm-diameter Circle Region of the Macular Fovea (CCD1) and the 1 mm to 3 mm Ring-like Region of the Macular fovea (CCD1-3) while the CT was measured at the fovea and at distances of 0.5mm and 2.5mm from fovea for the following points: nasal; temporal; superior; and inferior to the fovea. Both of them were measured by Optical coherence tomography angiography (OCTA) preoperatively as baseline and at 1 day, 1 week, 1 month, 3 months postoperatively. Other data collected included demographic information, the amplitude of accommodation (AA), intraocular pressure, axial length, and spherical equivalent.

Results : At preoperatively and 1 day, 1 week, 1 month, 3 months postoperatively, the CCD1 were 63.39% ± 0.25%, 61.82% ± 0.32%, 62.67% ±0.22%, 63.34% ± 0.25%, 63.14% ± 0.27%. It was significantly lower postoperatively compared with the preoperative. However, the CCD1 decreased firstly and then increased, similar trend also occured in CCD1-3. CCD1 at 1m postoperatively and CCD1-3 at 1w postoperatively had recovered to the baseline statistically. In addition to it, the CT was significantly thicker postoperatively compared with the preoperative and recovered to the baseline at 3m postoperatively. However, there was no obvious correlation between CCD and CT through the followed-up study.

Conclusions : The CCD and CT changed following Femto-LASIK in myopic patients which was a temporary change rather than a really irreversible damage to choroicapillary and the recovery time was longer in fovea than in surrounding area.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Fig.1 Changed trend of the CCD(1, 1-3)-Fovea with the followed-up time.
*. P<0.05(compared with the baseline value-preoperatively).

 

Fig.2 Changed trend of the foveal CT-Fovea with the followed-up time.
*. P<0.05(compared with the baseline value-preoperatively).