July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Retinotopic Imaging of the Central Visual Pathway in Optic Nerve and Outer Retinal Disease
Author Affiliations & Notes
  • Vivek R. Patel
    USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Eric Jung
    Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States
  • Jeiran Choupan
    The Laboratory for Functional and Computational Vision, USC Dornsife, Dana and David Dornsife College of Letters, Arts and Science, Department of Psychology, Los Angeles, California, United States
  • Chris Purington
    The Laboratory for Functional and Computational Vision, USC Dornsife, Dana and David Dornsife College of Letters, Arts and Science, Department of Psychology, Los Angeles, California, United States
  • Noelle Stiles
    Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States
  • Jessica Ijams Wolfing Morgan
    Center for Advanced Retinal and Ocular Therapeutics, Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Andrew S Bock
    Neurology, University of Pennsylvania, Philadelphia, California, United States
  • Kimberly Kinga Gokoffski
    USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
    Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States
  • Junyan Wang
    Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Meng Law
    Radiology, Neurology, Neurological Surgery, and Biomedical Engineering, Keck School of Medicine of USC, Los Angeles, California, United States
    Viterbi School of Engineering , University of Southern California, Los Angeles, California, United States
  • Amir H Kashani
    USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Andrew A Moshfeghi
    USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Hossein Ameri
    USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Geoffrey K. Aguirre
    The Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States
  • James D. Weiland
    Departments of Biomedical Engineering and Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States
  • Yonggang Shi
    Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Vivek Patel, None; Eric Jung, None; Jeiran Choupan, None; Chris Purington, None; Noelle Stiles, None; Jessica Morgan, None; Andrew Bock, None; Kimberly Gokoffski, None; Junyan Wang, None; Meng Law, None; Amir Kashani, None; Andrew Moshfeghi, None; Hossein Ameri, None; Geoffrey Aguirre, None; James Weiland, None; Yonggang Shi, None
  • Footnotes
    Support  NIH Grant U01 EY025864-01, Arnold and Mabel Beckman Foundation
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1969. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Vivek R. Patel, Eric Jung, Jeiran Choupan, Chris Purington, Noelle Stiles, Jessica Ijams Wolfing Morgan, Andrew S Bock, Kimberly Kinga Gokoffski, Junyan Wang, Meng Law, Amir H Kashani, Andrew A Moshfeghi, Hossein Ameri, Geoffrey K. Aguirre, James D. Weiland, Yonggang Shi; Retinotopic Imaging of the Central Visual Pathway in Optic Nerve and Outer Retinal Disease. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1969.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Retinal pathology and resulting vision loss can lead to structural and functional alterations in the brain. The changes that take place in the central visual pathway have implications for sight-restoring treatments targeting the retina, but are poorly understood in the context of varying disease entities. In particular, optic neuropathies which result in inner retinal abnormalities may induce unique structural and functional changes in the brain compared to outer retinal disease due to the robust topographic organization of the inner retinal layers. Here, we study a representative sample of patients with non-arteritic anterior ischemic neuropathy (NAION), an optic nerve process, along with macular dystrophy, an outer retinal disease.

Methods : Subjects were recruited as part of our 4-year NIH-funded study and underwent retinal imaging and microperimetry assessment, as well as multimodal MRI imaging using the Human Connectomes Project protocol. The retinotopic organization between points along the central visual pathway and the retina allows brain measurements to be displayed on the same coordinates as a fundus image. Retinotopic coordinates for cortical areas V1-V3 were determined by fitting a deformable template to digital reconstruction of a patient’s cortex derived from T1-weighted MRI data.

Results : We present on 2 patients with outer retinal disease (juvenile macular dystrophy) and 5 patients with optic nerve disease (NAION). Co-registration of data allowed for the visualization of blue-laser auto-fluorescence images, microperimetry, and fMRI cortical response to be compared to one another in fundus coordinates. In both groups, regions of retinal pathology and microperimetric field loss corresponded with decreased fMRI V1 cortical BOLD response.

Conclusions : Utilizing high-definition retinal and neuroimaging techniques, the relationship between pathology in different layers of the retina and resulting downstream alterations in the brain can be elucidated with exceptional detail. Our preliminary data set suggests that optic neuropathy and outer retinal disease differ in their functional and structural implications along the CVP.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Ex. of outer retina disease (macular dystrophy) vs optic nerve disease (NAION). Areas of negative V1 cortical response correlated with retinal areas of complete scotoma in a subject with juvenile macular dystrophy, while the NAION subject did not show such a relationship.

Ex. of outer retina disease (macular dystrophy) vs optic nerve disease (NAION). Areas of negative V1 cortical response correlated with retinal areas of complete scotoma in a subject with juvenile macular dystrophy, while the NAION subject did not show such a relationship.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×