July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Ethnicity Based Differences in the Lamina Cribrosa Microstructure of Healthy Eyes
Author Affiliations & Notes
  • Katie Lucy
    Department of Ophthalmology, NYU Langone Eye Center, NYU School of Medicine, New York, New York, United States
  • Hiroshi Ishikawa
    Department of Ophthalmology, NYU Langone Eye Center, NYU School of Medicine, New York, New York, United States
  • Joel S Schuman
    Department of Ophthalmology, NYU Langone Eye Center, NYU School of Medicine, New York, New York, United States
  • Mengfei Wu
    Department of Ophthalmology, NYU Langone Eye Center, NYU School of Medicine, New York, New York, United States
    Division of Biostatistics, Departments of Population Health and Environmental Medicine, NYU School of Medicine , New York, New York, United States
  • Joong Won Shin
    Ophthalmology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea (the Republic of)
  • KYUNGRIM SUNG
    Ophthalmology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea (the Republic of)
  • Gadi Wollstein
    Department of Ophthalmology, NYU Langone Eye Center, NYU School of Medicine, New York, New York, United States
  • Footnotes
    Commercial Relationships   Katie Lucy, None; Hiroshi Ishikawa, None; Joel Schuman, Zeiss (P); Mengfei Wu, None; Joong Won Shin, None; KYUNGRIM SUNG, None; Gadi Wollstein, None
  • Footnotes
    Support  NIH: R01-EY013178, R01-EY025011
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2032. doi:
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      Katie Lucy, Hiroshi Ishikawa, Joel S Schuman, Mengfei Wu, Joong Won Shin, KYUNGRIM SUNG, Gadi Wollstein; Ethnicity Based Differences in the Lamina Cribrosa Microstructure of Healthy Eyes. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2032.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : It has been shown that Asians have a high prevalence of normal tension glaucoma, while Caucasians and African-Americans have predominantly high tension glaucoma. This study compared the lamina cribrosa (LC) microstructure of a cohort of Korean and American eyes in order to discern microstructure differences between the cohorts that could contribute to this phenomenon.

Methods : The optic nerve head of 53 healthy eyes (42 subjects; 38 Korean eyes and 15 American eyes, consisting of a mixture of Caucasian and African-American eyes) was scanned 3 times during the same session with Cirrus HD-OCT (Zeiss, Dublin CA). These scans were registered and averaged to increase LC visibility using a method we have previously described. The area of the ONH featuring clearly visible LC was delineated, and scans were semi-automatically analyzed within the delineated area to segment the LC microstructure in 3D. The LC measurements of beam thickness, pore diameter, and beam/pore ratio were compared using a hierarchical linear model taking ethnicity and age into account.

Results : Baseline characteristics were similar between the cohorts (Table 1). Mean pore diameter was on average 3.78μm bigger in Asian subjects compared to non-Asian subjects (p<0.001), and beam/pore ratio was 0.33 units smaller in Asian subjects (p<0.001). No differences were detected in beam thickness.

Conclusions : The in vivo microstructure of the LC varies among different ethnicities. Further research is needed to determine the cause, effect and clinical relevance of these differences.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

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