July 2018
Volume 59, Issue 9
ARVO Annual Meeting Abstract  |   July 2018
Diabetic Macular Ischemia: Angio-OCT measurement compared to fluorescein angiography
Author Affiliations & Notes
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    Commercial Relationships   JOSE FRANCISCO VALDEZ LOPEZ, None
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Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2799. doi:
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      JOSE FRANCISCO VALDEZ VALDEZ LOPEZ; Diabetic Macular Ischemia: Angio-OCT measurement compared to fluorescein angiography. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2799.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : We performed a retrospective cross-sectional comparative study to compare the avascular foveal zone (FAZ) obtained by fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) in patients with diabetic retinopathy (DR), with the same diagnostic device.

Methods : We analyzed the foveal avascular zone (FAZ) of 80 eyes of 40 patients with different stages of non-proliferative diabetic retinopathy, obtaining FA and OCTA images using the same device; the swept source DRI OCT (Triton, Topcon, Tokyo, Japan). The Wilcoxon signed-rank test was used to compare area measurements and p values of <0.05 were considered statistically significant. The quantification of macular nonperfusion in both FA and OCT angiography captured images was completed using ImageJ software (ImageJ, National Institutes of Health, Bethesda, MD), independently by 2 observers. The quantitative analyzes of FAZ were made using Statistical Package for Social Science 22.0 (IBM SPSS; IBM, Armonk, NY).

Results : Four eyes from 4 patients were excluded from the study due to a high quantity of motion artifacts. The ICCs for FAZ area measurements between 2 observers with respect to FA and OCTA were 0.96 (IC: 0.36–0.71) and 0.92 (IC: 0.35–0.79), respectively, demonstrating the reproducibility and consistency of the methodology. Patients presented a mean FA of 0.65 mm2 (95% IC, 0.46–0.90; p < 0.05). OCTA angiogram analysis demonstrated a mean of 0.58 mm2 (95% IC, 0.43–0.73; p < 0.05). These results demonstrate the ability of OCT-A to delimit the foveal avascular zone, being it easier for observers to identify and quantify it in comparison with fluorescein angiography

Conclusions : OCT-A is a non-invasive, easy and rapid test that allows us to obtain the foveal avascular area in diabetic patients, once it has been related as a visual prognostic factor and as a predictor of the response to antiangiogenic therapy.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.



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