July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Glycated Haemoglobin (HbA1c) levels correlate with superficial perifoveal network vessel and perfusion density assessed by optical coherence tomography angiography (OCTA) in type I Diabetes Mellitus: A large scale prospective OCTA study
Author Affiliations & Notes
  • Javier Zarranz-Ventura
    Institut Clinic de Oftalmologia (ICOF), Hospital Clinic Barcelona, Barcelona, Spain
  • Anibal Alé-Chilet
    Institut Clinic de Oftalmologia (ICOF), Hospital Clinic Barcelona, Barcelona, Spain
  • Marina Barraso
    Institut Clinic de Oftalmologia (ICOF), Hospital Clinic Barcelona, Barcelona, Spain
  • Teresa Hernandez
    Institut Clinic de Oftalmologia (ICOF), Hospital Clinic Barcelona, Barcelona, Spain
  • Cristian Oliva
    Institut Clinic de Oftalmologia (ICOF), Hospital Clinic Barcelona, Barcelona, Spain
  • Marc Figueras-Roca
    Institut Clinic de Oftalmologia (ICOF), Hospital Clinic Barcelona, Barcelona, Spain
  • Anna Sala-Puigdollers
    Institut Clinic de Oftalmologia (ICOF), Hospital Clinic Barcelona, Barcelona, Spain
  • Irene Vinagre
    Institut Clinic de Malalties Digestives i Métaboliques (ICMDM), Hospital Clinic Barcelona, Barcelona, Spain
  • Emilio Ortega
    Institut Clinic de Malalties Digestives i Métaboliques (ICMDM), Hospital Clinic Barcelona, Barcelona, Spain
  • Enric Esmatjes
    Institut Clinic de Malalties Digestives i Métaboliques (ICMDM), Hospital Clinic Barcelona, Barcelona, Spain
  • Alfredo Adán
    Institut Clinic de Oftalmologia (ICOF), Hospital Clinic Barcelona, Barcelona, Spain
  • Footnotes
    Commercial Relationships   Javier Zarranz-Ventura, Alcon (R), Alimera Sciences (R), Allergan (C), Bausch & Lomb (R), Bayer (C), Brill Pharma (R), DORC (R), Novartis (R), Topcon (R), Zeiss (R); Anibal Alé-Chilet, None; Marina Barraso, None; Teresa Hernandez, None; Cristian Oliva, None; Marc Figueras-Roca, None; Anna Sala-Puigdollers, None; Irene Vinagre, None; Emilio Ortega, None; Enric Esmatjes, None; Alfredo Adán, None
  • Footnotes
    Support  Fundació Marató TV3, Marató 2015, Diabetes y Obesidad, Project 435/U/2016
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2802. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Javier Zarranz-Ventura, Anibal Alé-Chilet, Marina Barraso, Teresa Hernandez, Cristian Oliva, Marc Figueras-Roca, Anna Sala-Puigdollers, Irene Vinagre, Emilio Ortega, Enric Esmatjes, Alfredo Adán; Glycated Haemoglobin (HbA1c) levels correlate with superficial perifoveal network vessel and perfusion density assessed by optical coherence tomography angiography (OCTA) in type I Diabetes Mellitus: A large scale prospective OCTA study. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2802. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To assess the relationship between optical coherence tomography angiography (OCTA)-derived parameters and systemic levels of glycated haemoglobin (HbA1c) in a large cohort of type 1 Diabetes Mellitus (DM) patients.

Methods : Prospective, interventional OCTA study. 612 eyes of 308 type 1 DM patients with recent blood tests underwent a comprehensive ocular exam which included a specifically designed OCTA battery of images. OCTA scanning protocols included 3x3 and 6x6 mm (Cirrus Zeiss AngioPlex). Quantitative analysis was performed using the manufacturer built-in commercially available software. Vascular density (VD) and perfusion density (PD) measurements of the superficial vascular plexus were analyzed. Glycated Haemoglobin (HbA1c) levels were systematically obtained from last 5 years (2013-2017) yearly reviews in the Diabetes Unit, including a recent determination within 1 month of OCTA capture. Mean HbA1c levels were determined as an average of these 5 measurements as an adequate value of DM status control over last 5 years. To reduce the risk of bias eyes were randomized 1:1 and only 1 eye per patient was included in the analysis.

Results : Three groups were created and all study eyes were classified as per their mean HbA1c levels over the last 5-year period, HbA1c <6.5% (n=22), HbA1c 6.5-7.5% (n=113) and HbA1c >7.5% (n=173). Greater mean HbA1c levels were significantly associated with lower vessel density and perfusion density in both the 3x3 mm (p=0.004, p=0.034) and the 6x6 mm cubes (p=0.015, p=0.033). A significant correlation was observed between mean HbA1c levels and VD (R=-0.18, p=0.002) and PD (R=-0.14, p=0.017) in the 3x3mm and also in the 6x6mm OCTA cubes (VD: R=-0.14, p=0.012 and PD: R=-0.12, p=0.038). These correlations remained significant after controlling by diabetic retinopathy status, duration of DM disease and age for almost all parameters.

Conclusions : Mean HbA1c levels of previous 5 years correlate with OCTA-derived parameters in the macula of type 1 DM patients. These parameters may be a robust marker of adequate vs inadequate past diabetic control in patients with no documented previous medical records.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×