July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Assessing Response of Retinal Microvasculature Density and Morphology to Intra-vitreal Dexamethasone Implant Injections for Ocular Inflammatory Disease with Spectral Domain Optical Coherence Tomography Angiography (SD-OCTA)
Author Affiliations & Notes
  • Youning Zhang
    Ophthalmology, USC Roski Eye Institute Keck School of Medicine, Los Angeles, California, United States
  • Brian Do
    Ophthalmology, USC Roski Eye Institute Keck School of Medicine, Los Angeles, California, United States
  • Debarshi Mustafi
    Ophthalmology, USC Roski Eye Institute Keck School of Medicine, Los Angeles, California, United States
  • Kaitlin Kogachi
    Ophthalmology, USC Roski Eye Institute Keck School of Medicine, Los Angeles, California, United States
  • Zhongdi Chu
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Ruikang K Wang
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Damien C Rodger
    Ophthalmology, USC Roski Eye Institute Keck School of Medicine, Los Angeles, California, United States
  • Narsing A Rao
    Ophthalmology, USC Roski Eye Institute Keck School of Medicine, Los Angeles, California, United States
  • Amir H Kashani
    Ophthalmology, USC Roski Eye Institute Keck School of Medicine, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Youning Zhang, None; Brian Do, None; Debarshi Mustafi, None; Kaitlin Kogachi, None; Zhongdi Chu, None; Ruikang Wang, Carl Zeiss Meditec, Inc (C), Carl Zeiss Meditec, Inc (P), Insight Photonic Solutions (C), Kowa, Inc (P); Damien Rodger, Allergan (C), Allomind (C), Mini Pumps LLC (P), NeuroRecovery Technologies (P), Second Sight Medical Products, Inc. (P); Narsing Rao, None; Amir Kashani, Carl Zeiss Meditec (F), Carl Zeiss Meditec (R)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2835. doi:https://doi.org/
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      Youning Zhang, Brian Do, Debarshi Mustafi, Kaitlin Kogachi, Zhongdi Chu, Ruikang K Wang, Damien C Rodger, Narsing A Rao, Amir H Kashani; Assessing Response of Retinal Microvasculature Density and Morphology to Intra-vitreal Dexamethasone Implant Injections for Ocular Inflammatory Disease with Spectral Domain Optical Coherence Tomography Angiography (SD-OCTA). Invest. Ophthalmol. Vis. Sci. 2018;59(9):2835. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Previous studies suggest parafoveal capillary plexi have lower vascular density and complexity in eyes affected by ocular inflammatory disease. This study aims to evaluate changes in SD-OCTA-based metrics of density and morphology in inflammatory disease in response to dexamethasone implant injections.

Methods : A retrospective, observational, longitudinal, Institutional Review Board-approved study of 7 patients (10 eyes) with ocular inflammatory disease treated with dexamethasone injections. The 3x3-mm SD-OCTA scans centered on the fovea were imaged with the ZEISS AngioPlexTM SD-OCTA device (Cirrus, Carl Zeiss Meditec, Dublin, CA, USA) pre- and post-injection with intravitreal dexamethasone implant (Ozurdex®, Allergan, Irvine, CA). A semi-automated segmentation algorithm was used to assess microvasculature in the superficial (SRL), deep (DRL) and full-thickness (RET) retinal layers. The OCTA-based metrics included vessel area density (VAD), vessel skeleton density (VSD), vessel diameter index (VDI), vessel perimeter index (VPI), and vessel complexity index (VCI). Statistical analysis was performed using paired-sample T-tests.

Results : Mean VAD (0.41±0.02 vs 0.41±0.03), VSD (0.14±0.01 vs 0.14±0.01), VDI (2.99±0.08 vs 2.97±0.11), VPI (0.34±0.02 vs 0.34±0.02), and VCI (6.90x108±3.90x108 vs 6.97x108±5.68x108) in SRL were not significantly different before and after the injection (p>0.30 for all). Mean VAD (0.36±0.03 vs 0.36±0.03), VSD (0.14±0.01 vs 0.14±0.01), VDI (2.64±0.12 vs 2.65±0.16), VPI (0.32±0.02 vs 0.31±0.03), and VCI (6.86x108±4.76x107 vs 6.89x108±5.76x108) in DRL were not significantly different before and after the injection either (p>0.43 for all). Mean injection number was 2.7 ±0.88. Mean time length between pre- and post-dexamethasone imaging was 359.6±82 days.

Conclusions : While there appeared to be a trend towards a difference in the previously described vascular indices prior to and following injection, the study did not show a statistically significant effect on SD-OCTA-based metrics following intravitreal dexamethasone injections in eyes with ocular inflammatory disease. Larger sample size and power may have a significant impact on future results.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Superficial and deep retinal layer 3x3-mm SD-OCTA pre- and post-Ozurdex.

Superficial and deep retinal layer 3x3-mm SD-OCTA pre- and post-Ozurdex.

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