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Weizhong Lan, Longbo Wen, Lei Li, Xiang Li, Haogang Zhu, Zhikuan Yang; The correlation between an objective index summarizing individual environmental risk factors and the change of refractive error. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3393.
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© ARVO (1962-2015); The Authors (2016-present)
we have previously introduced a novel device ClouclipTM to record dynamically viewing distance and eye-received illuminance, the two known environmental risk factors (ERF) of myopia (2016 ARVO abstract: IOVS, 2016, Vol.57, 2491), and identified the correlation between these factors and refractive error (2017 ARVO abstract: 2017, Vol.58, 2403). Here we introduce an index to summarize whether or not one’s overall ERF is myopicgenic in a quantitative fashion (a negative value indicates myopicgenic and a positive value indicates hyperopicgenic; this part is submitted as another abstract this year) and investigate the correlation between the ERF index and the change of refractive error over time.
The ERF of subjects were measured via ClouclipTM for a period of a week with 6 months apart, along with the measurement of refractive error via cycloplegic autorefraction. The change of individual ERF index over time was compared by paired-t test, and correlated with individual baseline as well as the change of refractive error, respectively, by Person’ correlation analysis.
Ninety Grade 4 subjects (Age: 10-12y, Mean +/- SD of SER: 0.20+/- 1.08D) completed the 6-month measurement of ERF, the index was found decreased significantly (t=7.23, p<0.001), indicating myopicgenic behavior occurred during these period. No correlation was found between individual baseline refractive error and the change of ERF index (r=0.03, P=0.33). Nevertheless, significant positive correlation was found between the change of the ERF index and the refractive change (r=0.04, P=0.02) for the 14 subjects (baseline SER: -0.20 +/- 1.05D; refractive change: -0.27 +/- 0.25D) who have completed the 6-month refractive measurement until now.
The results provide objective evidence to support environmental role in myopia development. More convincing date will be obtained in the further follow-up study.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
ERF index of all participants. Red: baseline ERF index; Black: 6-month ERF index; Blue: the difference of ERF over the 6-month period.
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