July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
The correlation between an objective index summarizing individual environmental risk factors and the change of refractive error
Author Affiliations & Notes
  • Weizhong Lan
    Aier School of Ophthalmology , Central South University, Changsha, China
  • Longbo Wen
    Aier School of Ophthalmology , Central South University, Changsha, China
  • Lei Li
    Beihang University, Beijing, China
  • Xiang Li
    .Glasson Technology Co. Ltd, Hangzhou, China
  • Haogang Zhu
    Beihang University, Beijing, China
  • Zhikuan Yang
    Aier School of Ophthalmology , Central South University, Changsha, China
  • Footnotes
    Commercial Relationships   Weizhong Lan, Glasson Technology Co. Ltd (C); Longbo Wen, None; Lei Li, None; Xiang Li, Glasson Technology Co. Ltd, (S); Haogang Zhu, None; Zhikuan Yang, Glasson Technology Co. Ltd, (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3393. doi:
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      Weizhong Lan, Longbo Wen, Lei Li, Xiang Li, Haogang Zhu, Zhikuan Yang; The correlation between an objective index summarizing individual environmental risk factors and the change of refractive error. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3393.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : we have previously introduced a novel device ClouclipTM to record dynamically viewing distance and eye-received illuminance, the two known environmental risk factors (ERF) of myopia (2016 ARVO abstract: IOVS, 2016, Vol.57, 2491), and identified the correlation between these factors and refractive error (2017 ARVO abstract: 2017, Vol.58, 2403). Here we introduce an index to summarize whether or not one’s overall ERF is myopicgenic in a quantitative fashion (a negative value indicates myopicgenic and a positive value indicates hyperopicgenic; this part is submitted as another abstract this year) and investigate the correlation between the ERF index and the change of refractive error over time.

Methods : The ERF of subjects were measured via ClouclipTM for a period of a week with 6 months apart, along with the measurement of refractive error via cycloplegic autorefraction. The change of individual ERF index over time was compared by paired-t test, and correlated with individual baseline as well as the change of refractive error, respectively, by Person’ correlation analysis.

Results : Ninety Grade 4 subjects (Age: 10-12y, Mean +/- SD of SER: 0.20+/- 1.08D) completed the 6-month measurement of ERF, the index was found decreased significantly (t=7.23, p<0.001), indicating myopicgenic behavior occurred during these period. No correlation was found between individual baseline refractive error and the change of ERF index (r=0.03, P=0.33). Nevertheless, significant positive correlation was found between the change of the ERF index and the refractive change (r=0.04, P=0.02) for the 14 subjects (baseline SER: -0.20 +/- 1.05D; refractive change: -0.27 +/- 0.25D) who have completed the 6-month refractive measurement until now.

Conclusions : The results provide objective evidence to support environmental role in myopia development. More convincing date will be obtained in the further follow-up study.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

ERF index of all participants.
Red: baseline ERF index; Black: 6-month ERF index; Blue: the difference of ERF over the 6-month period.

ERF index of all participants.
Red: baseline ERF index; Black: 6-month ERF index; Blue: the difference of ERF over the 6-month period.

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