July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Hand held OCT probe optimized for supine optical coherence tomography angiography
Author Affiliations & Notes
  • Christian Viehland
    Biomedical Engineering, Duke University, Durham, North Carolina, United States
  • Du Tran-Viet
    Ophthalmology , Duke University, Durham, North Carolina, United States
  • Moseph Jackson-Atogi
    Ophthalmology , Duke University, Durham, North Carolina, United States
  • Xi Chen
    Ophthalmology , Duke University, Durham, North Carolina, United States
  • Lejla Vajzovic
    Ophthalmology , Duke University, Durham, North Carolina, United States
  • Cynthia A Toth
    Ophthalmology , Duke University, Durham, North Carolina, United States
    Biomedical Engineering, Duke University, Durham, North Carolina, United States
  • Joseph A. Izatt
    Biomedical Engineering, Duke University, Durham, North Carolina, United States
    Ophthalmology , Duke University, Durham, North Carolina, United States
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3920. doi:
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    • Get Citation

      Christian Viehland, Du Tran-Viet, Moseph Jackson-Atogi, Xi Chen, Lejla Vajzovic, Cynthia A Toth, Joseph A. Izatt; Hand held OCT probe optimized for supine optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3920.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We have previously reported on a custom, ultra-light, hand held swept source probe for routine bedside imaging of infants in the intensive care nursery (ICN). This work describes the development of a new, novel, hand held probe with a larger field of view that is capable of hand held optical coherence tomography angiography (HH-OCTA) in supine subjects. HH-OCTA will allow for OCTA imaging of traditionally non-compliant patients such as infants in the ICN.

Methods : A custom hand held probe was developed using a novel design incorporating diverging light on the scanner to accomplish diffraction limited performance over a 9.5x9.5 mm field of view on the retina. This system uses a 200 kHz 1060 nm swept source OCT engine, has 101 dB peak sensitivity, and 12 micron axial resolution. Under a protocol approved by the Duke Institutional review board, OCT volumes and OCTA images were acquired on an undilated, healthy adult volunteer in a supine position. OCT volumes were taken over an approximately 10x10 field of view with 1000 A-scans/B-scan and 128 B-scans/volume. OCTA images were taken of the central macula and peripapillary area over approximately 3x3 mm and 1.5x1.5 mm fields of view respectively. OCTA images were acquired with 300 A-scans/B-scan, 300 B-scans/volume, with 4 repeat scans at each B-scan location. OCTA images were generated in post processing using speckle variance and graph cut based segmentation was used to create projections of the vasculature.

Results : The custom probe, B-scans, and OCTA images of the central macula and peripapillary area of a healthy volunteer are shown in figure 1. HH-OCTA of the central macula shows fine perifoveal capillaries defining the foveal avascular zone. HH-OCTA of the peripapillary area shows larger retinal vessels as well as the peripapillary capillary network emerging radially from the optic nerve head.

Conclusions : We have demonstrated HH-OCTA in a healthy normal adult in a supine position. HH-OCTA was able to show fine vascular features and it will allow for OCTA imaging of traditionally non-compliant patients.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Figure 1: Top: B-scan excerpts from the same volume showing the central macula (left) and peripapillary area (right) of a healthy adult volunteer. Bottom: Custom hand held probe (left), HH-OCTA from the central macula (middle), and HH-OCTA of the superficial vasculature in the peripapillary area (right).

Figure 1: Top: B-scan excerpts from the same volume showing the central macula (left) and peripapillary area (right) of a healthy adult volunteer. Bottom: Custom hand held probe (left), HH-OCTA from the central macula (middle), and HH-OCTA of the superficial vasculature in the peripapillary area (right).

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