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Mateus Matuoka, Katia Santos, Natasha Cruz, Niro Kasahara; Correlation between the translaminar pressure gradient and the ocular perfusion pressure in glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5086.
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Despite an adequate intraocular pressure control, some patients with glaucoma remains losing their retinal ganglion cells and consequently, their visual function. Clinical variables such as the translaminar pressure gradient (PTL) and the ocular perfusion pressure (PPO) play a role in the glaucomatous optic neuropathy. However, the influence of these pressures is not clear in glaucoma. This was a cross-sectional clinical analysis study to correlate the PTL and the PPO in glaucoma patients.
The sample comprised 75 subjects, including patients with open angle glaucoma and normal patients. All patients underwent an ophthalmic evaluation, clinical measurements (blood pressure, height, and weight), and optical coherence tomography examination. PTL and PPO were calculated for each patient using proxy algorithms to attain indirect surrogate parameter values. Patients were distributed according to the severity of disease. The association of these data was performed with linear and non-linear regression analysis. Casual differences among the groups were compared with Fisher`s exact test for the categorical variables and ANOVA test for the continual variables.
A negative correlation between PTL and PPO was found (r = -0,628 [CI95%, from -0,747 to -0,466], P < 0,0001) – i.e. glaucoma patients with higher PTL presented with lower OPP. Figure 1 shows the dispersion figure using linear regression model while figure 2 shows the figure using non-linear regression model.
Glaucoma patients with higher PTL presented with lower PPO. Further researches are required to determine whether this association is causal or independent.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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