July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Effectiveness and Safety of a phototherapeutic contact lens for Diabetic Retinopathy
Author Affiliations & Notes
  • Qianhui Yang
    Department of Ophthalmology, USC Roski Eye Institute, Los Angeles, California, United States
    USC Institute of Biomedical Therapeutics, University of Southern California, Los Angeles, California, United States
  • Juan Carlos Martinez-Camarillo
    Department of Ophthalmology, USC Roski Eye Institute, Los Angeles, California, United States
    USC Institute of Biomedical Therapeutics, University of Southern California, Los Angeles, California, United States
  • Colin A. Cook
    Micro-ElectroMechanical Systems Lab, California Institute of Technology, Pasadena, California, United States
  • Nicholas Scianmarello Scianmarello
    Micro-ElectroMechanical Systems Lab, California Institute of Technology, Pasadena, California, United States
  • Yu-Chong Tai
    Micro-ElectroMechanical Systems Lab, California Institute of Technology, Pasadena, California, United States
  • Amir H Kashani
    Department of Ophthalmology, USC Roski Eye Institute, Los Angeles, California, United States
    USC Institute of Biomedical Therapeutics, University of Southern California, Los Angeles, California, United States
  • Mark S. Humayun
    Department of Ophthalmology, USC Roski Eye Institute, Los Angeles, California, United States
    USC Institute of Biomedical Therapeutics, University of Southern California, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Qianhui Yang, None; Juan Carlos Martinez-Camarillo, None; Colin Cook, None; Nicholas Scianmarello Scianmarello, None; Yu-Chong Tai, None; Amir Kashani, None; Mark Humayun, None
  • Footnotes
    Support  Whittier foundation; USC IBT, USC Roski Eye Institute and RPB support
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5814. doi:
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      Qianhui Yang, Juan Carlos Martinez-Camarillo, Colin A. Cook, Nicholas Scianmarello Scianmarello, Yu-Chong Tai, Amir H Kashani, Mark S. Humayun; Effectiveness and Safety of a phototherapeutic contact lens for Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5814.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Diabetic retinopathy (DR) is a leading complication of diabetes. It is thought that increased rod metabolism under dark adaptation exacerbates hypoxia in diabetic retina. Nowadays most treatments for DR are invasive and need multiple clinic visits. Recently a phototherapeutic contact lens has been designed to provide illumination to retina as a means to supress dark adaptation. It may be possible to delay the progression of DR. The purpose of this study is to explore the bioactivity and safety of this device.

Methods : Six eyes from three healthy mature white New Zealand rabbits were used. The phototherapeutic contact lens was placed on treated eye. An non-phototherapeutic contact lens was used on the fellow eye as a control. To determine bioactivity of photoreceptors, an ERG was performed. Flash response, including amplitude and implicit time on scotopic condition were analyzed at different flash intensities (100, 300, 1000, 3000, 10000, 25000 mcd.s/m2, respectively). Animals were under a 20-minutes period of dark adaption before any ERG. Then the contact lens were swapped on the eyes and the ERG were repeated. The whole process was performed in a dark room under dim red light. Once ERG were completed, the phototherapeutic contac lens was sutured to the eye for a long–term period (28 days) to verify safety. There will be a statistical analysis using Graph Pad Prism 7.0, determining the degree of correlation between the groups. Histological analysis will be performed to determine safety.

Results : The ERG showed that both the amplitude and implicit time of b-wave in the treated eye were significantly shorter than the untreated eye under scotopic conditions (Figure 1). No significant difference in the amplitude and implicit time of a-wave was observed. A representative plot (Figure 2) shows significant depression of b-wave, both in the amplitude and implicit time (amplitude: p=0.01; implicit time: p<0.001).

Conclusions : The phototherapeutic contact lens can effectively reduce the bioactivity of the retina, without ocular side effects in an acute follow-up. Further studies should be performed for a long-term placement in both healthy and retinal ischemic animal models to determine whether this device can reduce oxygen consumption in retina and delay disease progression. Long-term histology from contact lens safety is on going and will be presented.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

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