Abstract
Purpose :
To describe optical coherence tomography angiography (OCTA) characteristics in eyes with punctate inner choroidopathy (PIC), and evaluate the therapeutic effects of immunosuppression on OCTA abnormalities in the outer retina and inner choroid.
Methods :
Retrospective review of 10 PIC patients. Each patient underwent OCTA, fundus autofluorescence (FAF), fluorescein angiography (FA), and indocyanine green angiography (ICGA). A subgroup of 5 patients who required treatment were followed longitudinally. Choriocapillaris (CC) flow void area, foveal avascular zone (FAZ), and total vessel area (TVA) for both the deep and superficial retinal capillary plexi (DCP & SCP) were evaluated by OCTA before and after treatment.
Results :
There were no SCP lesions on OCTA in PIC patients. In DCP, the only abnormality noted was caused by the superior portion of a prominent CNV. There were 3 distinct CC lesions noted: 1)hyperintense vascular formations, 2) hypofluorescent lesions with visible sattler vessels, 3)hypoflourescent lesions devoid of any visible vascular structure (CC flow voids). These flow voids corresponded to areas of hypocyanescence on ICG.
During the active stage, all eyes showed CC flow voids that correlated with both OCT and ICG lesions. After treatment, CC flow void improved significantly (p=0.031). Treatment did not change the TVA or FAZ of the retinal plexi.
Conclusions :
In PIC, OCTA may help differentiate isolated inflammatory lesions from those associated with CNV, which is important in determining treatment approach. OCTA derived parameters may be a useful adjunct for monitoring treatment response to immunosuppression.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.