July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Optical coherence tomography angiography assessment of choriocapillaris and outer retinal alterations in punctate inner choroidopathy and the vascular response to treatment.
Author Affiliations & Notes
  • Ian Thompson
    National Eye Institute, Silver Spring, Maryland, United States
  • Osama Sabbagh
    National Eye Institute, Silver Spring, Maryland, United States
  • Sonny Caplash
    National Eye Institute, Silver Spring, Maryland, United States
  • Shuk Kei Cheng
    National Eye Institute, Silver Spring, Maryland, United States
  • Benjamin Chaon
    National Eye Institute, Silver Spring, Maryland, United States
  • Chinwe Okeagu
    National Eye Institute, Silver Spring, Maryland, United States
  • H Nida Nida Sen
    National Eye Institute, Silver Spring, Maryland, United States
  • Footnotes
    Commercial Relationships   Ian Thompson, None; Osama Sabbagh, None; Sonny Caplash, None; Shuk Kei Cheng, None; Benjamin Chaon, None; Chinwe Okeagu, None; H Nida Sen, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1536. doi:
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      Ian Thompson, Osama Sabbagh, Sonny Caplash, Shuk Kei Cheng, Benjamin Chaon, Chinwe Okeagu, H Nida Nida Sen; Optical coherence tomography angiography assessment of choriocapillaris and outer retinal alterations in punctate inner choroidopathy and the vascular response to treatment.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1536.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe optical coherence tomography angiography (OCTA) characteristics in eyes with punctate inner choroidopathy (PIC), and evaluate the therapeutic effects of immunosuppression on OCTA abnormalities in the outer retina and inner choroid.

Methods : Retrospective review of 10 PIC patients. Each patient underwent OCTA, fundus autofluorescence (FAF), fluorescein angiography (FA), and indocyanine green angiography (ICGA). A subgroup of 5 patients who required treatment were followed longitudinally. Choriocapillaris (CC) flow void area, foveal avascular zone (FAZ), and total vessel area (TVA) for both the deep and superficial retinal capillary plexi (DCP & SCP) were evaluated by OCTA before and after treatment.

Results : There were no SCP lesions on OCTA in PIC patients. In DCP, the only abnormality noted was caused by the superior portion of a prominent CNV. There were 3 distinct CC lesions noted: 1)hyperintense vascular formations, 2) hypofluorescent lesions with visible sattler vessels, 3)hypoflourescent lesions devoid of any visible vascular structure (CC flow voids). These flow voids corresponded to areas of hypocyanescence on ICG.

During the active stage, all eyes showed CC flow voids that correlated with both OCT and ICG lesions. After treatment, CC flow void improved significantly (p=0.031). Treatment did not change the TVA or FAZ of the retinal plexi.

Conclusions : In PIC, OCTA may help differentiate isolated inflammatory lesions from those associated with CNV, which is important in determining treatment approach. OCTA derived parameters may be a useful adjunct for monitoring treatment response to immunosuppression.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

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