July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Relationship between corneal hysteresis and positional change in intraocular pressure in healthy adults
Author Affiliations & Notes
  • Sayoko Eileen Moroi
    Ophthalmology & Visual Sciences, Univ of Michigan-Kellogg Eye Ctr, Ann Arbor, Michigan, United States
  • Simone Ferguson
    Ophthalmology & Visual Sciences, Univ of Michigan-Kellogg Eye Ctr, Ann Arbor, Michigan, United States
  • David M Reed
    Ophthalmology & Visual Sciences, Univ of Michigan-Kellogg Eye Ctr, Ann Arbor, Michigan, United States
  • Vikas Gulati
    Ophthalmology and Visual Sciences,, University of Nebraska Medical Center, Omaha, Nebraska, United States
  • Arash Kazemi
    Ophthalmology, The Mayo Clinic, Rochester, Minnesota, United States
  • Arthur J Sit
    Ophthalmology, The Mayo Clinic, Rochester, Minnesota, United States
  • David C Musch
    Ophthalmology & Visual Sciences, Univ of Michigan-Kellogg Eye Ctr, Ann Arbor, Michigan, United States
    Epidemiology, University of Michigan , Ann Arbor, Michigan, United States
  • Carol B Toris
    Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States
  • Footnotes
    Commercial Relationships   Sayoko Moroi, NIH (F); Simone Ferguson, None; David Reed, None; Vikas Gulati, None; Arash Kazemi, None; Arthur Sit, Research to Prevent Blindness (F); David Musch, Research to Prevent Blindness (F); Carol Toris, None
  • Footnotes
    Support  NIH R01EY022124
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2023. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Sayoko Eileen Moroi, Simone Ferguson, David M Reed, Vikas Gulati, Arash Kazemi, Arthur J Sit, David C Musch, Carol B Toris; Relationship between corneal hysteresis and positional change in intraocular pressure in healthy adults. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2023.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Prior studies show that low cornea hysteresis (CH) is associated with increased risk of glaucoma, progression, and a greater intraocular pressure (IOP) reduction following treatment. CH reflects the viscoelastic tissue properties with low CH in glaucoma associated with higher IOP and greater IOP response. However, the biomechanical relationship between CH and positional IOP variation is not known. We hypothesize an association between CH and positional change in IOP (ΔIOP) with higher CH associated with smaller ΔIOP in healthy eyes.

Methods : Participants with healthy eyes were enrolled in a multi-center trial (NCT 01677507) at Mayo Clinic, University of Michigan, and University of Nebraska. All underwent a comprehensive eye exam, CH, biometry measurements, IOPseated and IOPsupine measured by pneumatonometry, and physical measurements. The outcome measures included IOPseated, IOPsupine, ΔIOP (IOPsupine-IOPseated), and percent ΔIOP. Analysis included multiple linear regression and quantile regression to investigate the relationship between CH with both ΔIOP and percent ΔIOP.

Results : 92 participants (23 men, 69 women) were analyzed with a mean ± standard deviation of 56.3 ± 8.8 years. CH was 10.8 ± 1.6 mmHg in right eyes and 10.9 ± 1.7 mmHg in left eyes. IOPsupine was 20.9 ± 3.1 mmHg and IOPseated was 15.9 ± 2.7 mmHg with ΔIOP of 5.0 ± 1.8 mmHg in right eyes. IOPsupine was 20.9 ± 3.1 and IOPseated was 15.8 ± 2.6 mmHg with ΔIOP of 5.2 ± 1.9 in left eyes. The percent ΔIOP was 33% for right eyes and 34% for left eyes. There was no significant association between CH and ΔIOP by multiple linear regression analysis (see Figure R2, OD =-0.007, OS=0.041). After adjusting for percent ΔIOP the association remained insignificant. There was no association between CH and co-variates of sex, age, biometry, blood pressure, systemic medications, and body mass index to explain ΔIOP (see Table).

Conclusions : In participants with healthy eyes, our results do not support the hypothesis that CH is associated with IOP variation as measured by positional change in IOP. In these individuals with healthy eyes, the data represents normal-to-high CH values, so there is a limited range of CH specifically on the low CH values. The next phase of EDEN is enroll cases with glaucoma and ocular hypertension and thus test the association of CH and IOP variation in a case-control study design.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×