July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Reticular drusen and systemic disease in age-related macular degeneration
Author Affiliations & Notes
  • Celine Saade
    Ophthalmology, Brown University, Providence, Rhode Island, United States
  • Magdalena Krzystolik
    Ophthalmology, Brown University, Providence, Rhode Island, United States
  • Paul B. Greenberg
    Ophthalmology, Brown University, Providence, Rhode Island, United States
  • Footnotes
    Commercial Relationships   Celine Saade, None; Magdalena Krzystolik, None; Paul Greenberg, None
  • Footnotes
    Support  NONE
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2413. doi:
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      Celine Saade, Magdalena Krzystolik, Paul B. Greenberg; Reticular drusen and systemic disease in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2413.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the association between systemic disease and reticular drusen in age-related macular degeneration (AMD).

Methods :
In this retrospective study, 45 consecutive patients with early AMD according to AREDS classification and reticular drusen in at least one eye were assigned to the study group and were age-matched to 45 consecutive patients with early AMD without reticular drusen in at least one eye in the control group. The Charlson Comorbidity Index (CCI), cardiovascular (CV) risk factors and the status of the fellow eye were compared between both groups using the Student t-test and Chi-squared test.

Results :
The CCI score and CV risk factors were not statistically different between the study and control groups. Advanced AMD in the fellow eye was significantly more prevalent in patients with reticular drusen (p-0.02).

Conclusions :
In AMD, reticular drusen were significantly associated with more severe AMD but not with increased systemic disease burden.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Figure 1. Reticular drusen as seen on spectral domain optical coherence tomography (SD-OCT).

Figure 1. Reticular drusen as seen on spectral domain optical coherence tomography (SD-OCT).

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