July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Correlation of En Face OCTA Averaging versus Single Image Quantitative Measurements with Retinal Vein Occlusion Visual Outcomes
Author Affiliations & Notes
  • Jesse J Jung
    East Bay Retina Consultants, Inc., San Francisco, California, United States
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Michael H. Chen
    Carl Zeiss Meditec Inc., Dublin, California, United States
  • Yue Shi
    Doheny Eye Institute, Los Angeles, California, United States
    Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
  • Marco Nassisi
    Doheny Eye Institute, Los Angeles, California, United States
    Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
  • Kenneth Marion
    Doheny Eye Institute, Los Angeles, California, United States
    Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
  • Nathan Shemonski
    Carl Zeiss Meditec Inc., Dublin, California, United States
  • Srinivas R. Sadda
    Doheny Eye Institute, Los Angeles, California, United States
    Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
  • Quan V Hoang
    Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia College of Physicians and Surgeons, New York, New York, United States
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
  • Footnotes
    Commercial Relationships   Jesse Jung, Carl Zeiss Meditec, Inc. (C), Genentech/Roche (C), Google, Inc. (C), Notal Vision, Inc. (C); Michael Chen, Carl Zeiss Meditec, Inc. (C); Yue Shi, None; Marco Nassisi, None; Kenneth Marion, None; Nathan Shemonski, Carl Zeiss Meditec, Inc. (E); Srinivas Sadda, Carl Zeiss Meditec, Inc. (F); Quan Hoang, None
  • Footnotes
    Support  This work was supported in part by an unrestricted grant from Research to Prevent Blindness (RPB) and Career Development Awards from Research to Prevent Blindness (QVH) and K08 Grant (QVH, 1 K08 EY023595, National Eye Institute, NIH)
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2815. doi:
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    • Get Citation

      Jesse J Jung, Michael H. Chen, Yue Shi, Marco Nassisi, Kenneth Marion, Nathan Shemonski, Srinivas R. Sadda, Quan V Hoang; Correlation of En Face OCTA Averaging versus Single Image Quantitative Measurements with Retinal Vein Occlusion Visual Outcomes. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2815.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To demonstrate the effect of correlating multiple en face imaging averaging of quantitative metrics of the retinal microvasculature using optical coherence tomography angiography (OCTA) in Retinal Vein Occlusion (RVO) with best corrected visual acuity (BCVA)

Methods : Eyes with unilateral RVO and a normal contralateral eye were imaged in this cross-sectional study. Images had signal strength >7, uniform illumination, foveal centration, and minimal artifact or saccades. Spectral Domain OCTA images were acquired on each eye 5 times with the Cirrus 5000 Angioplex 3x3mm scan pattern (Carl Zeiss Meditec, Dublin, CA). Automated segmented scans were averaged with registration for the superficial retinal layer (SRL) and deep retinal layer (DRL) (Figure 1). Quantitative parameters including the size and circularity of the foveal avascular zone (FAZ) and parafoveal vessel density (VD) of the averaged versus single image were correlated to logMAR BCVA. Pearson correlation coefficient was performed to compare the average versus single groups; and univariate and stepwise multivariate linear regression with clustering on the individual level were performed to correlate quantitative metrics to BCVA

Results : Twenty eyes (10 patients, 5 male) with 6 having BRVO, 2 with HRVO and 2 with CRVO and mean age of 64.3 (range 47-88) were included. Mean LogMAR BCVA of the contralateral normal eyes was 0.056 (±std 0.064, Snellen 20/23 ±std 3.5); and the involved eye was 0.29 (±std 0.29, Snellen 20/49.1 ±std 36.8). Averaged VD of the SRL (p=0.02) and DRL (p=0.04) Inner Ring and SCP (p<0.01) and DCP (p<0.00) total VD was significantly less than the single image. In the multivariate linear regression when including all OCTA parameters that were significantly associated with BCVA on univariate analysis, overall, averaging resulted in an increased R2 value (from 0.93 to 0.95, for single and averaged groups, respectively). FAZ circularity was associated with BCVA with single images (coefficient -0.96, p=0.002), but not with averaging (p=0.063)

Conclusions : Averaging of en face OCTA images improves the clarity of vessels and may allow for more accurate quantification of VD and FAZ parameters. BCVA is associated with VD, but averaging does not necessarily improve the ability to accurately define this association compared to a single OCTA scan

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Figure 1. Averaged vs Single Images of the SRL and DRL

Figure 1. Averaged vs Single Images of the SRL and DRL

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