July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Age-dependence of the peripheral defocus of the isolated human crystalline lens
Author Affiliations & Notes
  • Fabrice Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Siobhan Williams
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Marco Ruggeri
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Ashik Mohamed
    Ophthalmic Biophysics, LV Prasad Eye Institute, Hyderabad, India
    Vision Cooperative Research Centre, Sydney, New South Wales, Australia
  • N. Geetha Sravani,
    Ophthalmic Biophysics, LV Prasad Eye Institute, Hyderabad, India
  • Bianca Maceo Heilman
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Yue Yao
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Alex Gonzalez
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • cornelis rowaan
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Arthur Ho
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Jean-Marie A Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Vision Cooperative Research Centre, Sydney, New South Wales, Australia
  • Footnotes
    Commercial Relationships   Fabrice Manns, None; Siobhan Williams, None; Marco Ruggeri, None; Ashik Mohamed, None; N. Geetha Sravani,, None; Bianca Maceo Heilman, None; Yue Yao, None; Alex Gonzalez, None; cornelis rowaan, None; Arthur Ho, None; Jean-Marie Parel, None
  • Footnotes
    Support  NEI Grants: R01EY021834, F31EY021444 (Maceo), P30EY14801 (Center Grant); the Florida Lions Eye Bank; Research to Prevent Blindness; Australian Federal Government CRC Program (Vision CRC); Drs. KR Olsen and ME Hildebrandt, Drs. Raksha Urs and Aaron Furtado, the Henri and Flore Lesieur Foundation (JMP); Hyderabad Eye Research Foundation.
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2978. doi:https://doi.org/
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      Fabrice Manns, Siobhan Williams, Marco Ruggeri, Ashik Mohamed, N. Geetha Sravani,, Bianca Maceo Heilman, Yue Yao, Alex Gonzalez, cornelis rowaan, Arthur Ho, Jean-Marie A Parel; Age-dependence of the peripheral defocus of the isolated human crystalline lens. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2978. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Recent studies suggest that peripheral refraction may be a factor in myopia onset and progression. Age-related changes in lens shape and refractive index gradient due to continuous lens growth with age may produce changes in the peripheral optics of the whole eye. The purpose of this study was to quantify the peripheral defocus of the isolated human crystalline lens and its age-dependence.

Methods : Data were acquired on 12 isolated human lenses obtained from the Ramayamma International Eye-Bank, Hyderabad, India (age: 6 to 56 years, post-mortem time: 1 to 5 days). The lenses were placed in a custom-built combined Laser-Ray Tracing and Optical Coherence Tomography system that measures the slopes of rays refracted through the lens for on-axis and off-axis incidence (Manns et al, ARVO 2016). Ray slope is measured directly by recording spot patterns as a function of axial position using an imaging sensor mounted on a motorized positioning stage below the lens. The wavelength of the incident beam is 880 nm. Experiments were performed with a raster scan with a spacing of 0.5 mm. The lens power was calculated for incidence angles ranging from -30o to +30o in 5o increments. At each angle, lens power was calculated by finding the axial position that minimizes the root-mean-square diameter of the spot pattern formed by the rays. The 49 central rays of the raster scan were used for the analysis, corresponding to a central 3 mm zone on axis. The age dependence of the on- and off-axis power and peripheral defocus (difference between off-axis and on axis power) was quantified.

Results : At all incidence angles, isolated lens power decreased significantly with age (Figure 1A). In all lenses, the lens power was found to increase as the incidence angle increases, corresponding to myopic peripheral defocus (Figure 1B). There was a statistically significant decrease of the peripheral defocus with age (Figure 2).

Conclusions : The results suggest that the continuous growth of the lens contributes significantly to the age-related changes in the peripheral optical performance of the whole eye.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Figure 1: (A) Isolated lens power as a function of age for 0o, 10o , 20o and 30o incidence angle. (B) Angular dependence of the lens power for 3 representative lenses (child, adolescent, adult).

Figure 1: (A) Isolated lens power as a function of age for 0o, 10o , 20o and 30o incidence angle. (B) Angular dependence of the lens power for 3 representative lenses (child, adolescent, adult).

 

Figure 2: Age-dependence of lens peripheral defocus at 25o and 30o.

Figure 2: Age-dependence of lens peripheral defocus at 25o and 30o.

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