July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Optical Coherence Tomography (OCT) Neural Canal Direction, Obliqueness and Minimum Cross-sectional Area in a Normal Population
Author Affiliations & Notes
  • Seung Woo Hong
    Optic nerve head research lab, Devers Eye Institute, Portland, Oregon, United States
    Department of Ophthalmology and Visual Sciences, Medical College, the Catholic university of Korea, Seoul, Korea (the Republic of)
  • Hongli Yang
    Optic nerve head research lab, Devers Eye Institute, Portland, Oregon, United States
  • Stuart Keith Gardiner
    Discoveries in Sight Research Labs, Devers Eye Institute, Portland, Oregon, United States
  • Haomin Luo
    Optic nerve head research lab, Devers Eye Institute, Portland, Oregon, United States
  • Christy Hardin
    Optic nerve head research lab, Devers Eye Institute, Portland, Oregon, United States
  • Glen Sharpe
    Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Joseph Caprioli
    Ophthalmology, UCLA David Geffen School of Medicine, Los Angeles, California, United States
  • Shaban Demirel
    Discoveries in Sight Research Labs, Devers Eye Institute, Portland, Oregon, United States
  • Christopher A Girkin
    Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Jeffrey M Liebmann
    Ophthalmology, Columbia University Medical Center, New York City, New York, United States
  • Christian Y Mardin
    Ophthalmology, Friedrich-Alexander University Erlangen-Nuremberg, Nuremberg, Germany
  • Harry A Quigley
    Ophthalmology, Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland, United States
  • Alexander Scheuerle
    University Eye Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
  • Brad Fortune
    Discoveries in Sight Research Labs, Devers Eye Institute, Portland, Oregon, United States
  • Balwantray C Chauhan
    Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Claude F Burgoyne
    Optic nerve head research lab, Devers Eye Institute, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Seung Woo Hong, None; Hongli Yang, None; Stuart Gardiner, Heidelberg Engineering (C); Haomin Luo, None; Christy Hardin, None; Glen Sharpe, None; Joseph Caprioli, Heidelberg Engineering (F); Shaban Demirel, Carl Zeiss Meditec (C), Heidelberg Engineering (C), Legacy Good Samaritan Foundation (F), NIH/NEI R01-EY-019674 (F); Christopher Girkin, Heidelberg Engineering (F); Jeffrey Liebmann, Aerie Phamaceuticals Inc. (C), Alcon Laboratories Inc. (C), Allergan Inc. (C), Bauch & Lomb (C), Carl Zeiss Meditech Inc. (C), Diopsys Corporation (I), FORSIGHT Vision 5 (C), FORSIGHT Vision 5 (I), Heidelberg Engineering (C), Heidelberg Engineering (F), Heidelberg Engineering (S), Inotek Pharmaceuticals Inc (C), National Eye Institute (S), Quark Phamaceuticals Inc. (C), Reichert Inc. (C), SOLX Inc (I), Sustained Nano System (I), Sustained Nano Systems (C); Christian Mardin, Heidelberg Engineering (F); Harry Quigley, Heidelberg Engineering (F); Alexander Scheuerle, Heidelberg Engineering (F); Brad Fortune, Inotek Pharmaceuticals (C), Legacy Good Samaritan Foundation (F); Balwantray Chauhan, Heidelberg Engineering (F), Heidelberg Engineering (C), Heidelberg Engineering (S); Claude Burgoyne, Heidelberg Engineering (C), Heidelberg Engineering (F), Heidelberg Engineering (S)
  • Footnotes
    Support  NIH/NEI R01-EY021281, Good Samaritan Eye Institute Foundation, Unrestricted research support Heidelberg Engineering
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3496. doi:https://doi.org/
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      Seung Woo Hong, Hongli Yang, Stuart Keith Gardiner, Haomin Luo, Christy Hardin, Glen Sharpe, Joseph Caprioli, Shaban Demirel, Christopher A Girkin, Jeffrey M Liebmann, Christian Y Mardin, Harry A Quigley, Alexander Scheuerle, Brad Fortune, Balwantray C Chauhan, Claude F Burgoyne; Optical Coherence Tomography (OCT) Neural Canal Direction, Obliqueness and Minimum Cross-sectional Area in a Normal Population. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3496. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To quantify the OCT-detected, optic nerve head (ONH) anatomic components of clinical “optic disc size”, we assessed the size and relative position of the anterior scleral canal opening (ASCO) relative to Bruch’s membrane opening (BMO) so as to determine the direction, obliqueness and minimum cross-sectional area of the neural canal (i.e. the neural canal minimum (NCM)) (Fig.1). We then assessed their correlation to retinal nerve fiber layer thickness (RNFLT), in 362 normal subjects.

Methods : One eye of each subject underwent RNFL circle scan and ONH OCT imaging (Spectralis) (24 enhanced depth ONH radial B-scans, aligned to the Fovea-BMO axis and centered on the BMO centroid). In each ONH B-scan, BMO, ASCO, and the Border Tissue of Elshnig were manually segmented. BMO and ASCO reference planes, centroids and area were determined. The neural canal axis was defined to be the vector connecting the BMO and ASCO centroids,(Fig 1B). Neural canal direction was defined by projecting the axis vector onto the BMO plane. Neural canal obliqueness was defined by the angle between the axis and a vector through BMO centroid, perpendicular to BMO plane. By convention, the angle was (+) if the axis pointed towards the chiasm, (nasally), and (-) if it pointed away from the chiasm, (temporally), (Fig.1B). To determine the NCM, BMO and ASCO points were projected onto a plane perpendicular to the axis vector, and the overlap area was identified (Fig. 1C). RNFLT was quantified within the circle scans. Correlations between BMO, ASCO, and NCM areas and RNFLT were assessed.

Results : ASCO area (mean ± standard deviation, (SD)) (2.23 ± 0.43 mm2) was greater than BMO area (1.83 ± 0.38 mm2), and both were greater than the NCM (1.34 ± 0.42 mm2, P<0.001, Fig. 2A). Neural canal direction was most commonly inferior nasal (55%, Fig. 2B). Mean neural canal obliqueness was +15.2 ± 20.3° (range -47.5° to +62.4°, Fig. 2C). The correlation between RNFLT and NCM (r=0.374, P<0.001) was stronger than the correlation with BMO area (r=0.266, comparison P=0.035), but not significantly different from ASCO area (r=0.338, P=0.490).

Conclusions : Our study establishes anatomic relationships between BMO, ASCO, neural canal direction, obliqueness, and the NCM. It additionally suggests that in normal eyes, NCM and ASCO area more strongly correlate to RNFLT than BMO area.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

 

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