July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan
Author Affiliations & Notes
  • Akira Kobayashi
    Dept of Ophthalmology, Kanazawa Univ Sch of Medicine, Kanazawa, ISHIKAWA, Japan
  • Tsubasa Nishino
    Dept of Ophthalmology, Kanazawa Univ Sch of Medicine, Kanazawa, ISHIKAWA, Japan
  • Hideaki Yokogawa
    Dept of Ophthalmology, Kanazawa Univ Sch of Medicine, Kanazawa, ISHIKAWA, Japan
  • Natsuko Mori
    Dept of Ophthalmology, Kanazawa Univ Sch of Medicine, Kanazawa, ISHIKAWA, Japan
  • Toshinori Masaki
    Dept of Ophthalmology, Kanazawa Univ Sch of Medicine, Kanazawa, ISHIKAWA, Japan
  • Kazuhisa Sugiyama
    Dept of Ophthalmology, Kanazawa Univ Sch of Medicine, Kanazawa, ISHIKAWA, Japan
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5760. doi:
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      Akira Kobayashi, Tsubasa Nishino, Hideaki Yokogawa, Natsuko Mori, Toshinori Masaki, Kazuhisa Sugiyama; A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5760.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : A 10-year review of endothelial keratoplasty (EK) procedures, Descemet’s stripping automated endothelial keratoplasty (DSAEK) and Descemet’s membrane endothelial keratoplasty (DMEK), and underlying diseases at a tertiary referral hospital in Japan.

Methods : We retrospectively reviewed all medical records of bullous keratopathies (BK) surgically treated by EK (DSAEK/DMEK) at Kanazawa University Hospital from January 2007 to December 2016. Changes or modifications to the annual number of EK procedures and underlying diseases were analyzed.

Results : During this period, 320 EK procedures (DSAEK: 288 cases, DMEK: 32 cases) were performed on 250 patients. Total annual EKs gradually increased from 19 to 45 cases between 2007 and 2016. The annual number of DSAEKs was stable, although the proportion of DSAEKs to other procedures decreased significantly as re-DSAEKs and DMEKs increased. BK after argon laser iridotomy (ALI) was the leading cause in 2007, followed by Fuchs’ endothelial dystrophy and failed penetrating keratoplasty. In 2016, BK after trabeculectomy (TLE) was most prevalent, followed by failed DSAEK, failed PK and pseudophakic BK. The decreased ALI and FED, and increased BK after trabeculectomy and failed DSAEK were statistically significant.

Conclusions : The distribution of EK procedures (DSAEK/DMEK) and underlying diseases changed over 10 years at a tertiary referral hospital in Japan. The proportion of re-DSAEK and DMEK increased among all EK procedures. Most significantly, among the underlying diseases, decrease ALI and FED and increased TLE and failed DSAEK were observed. Extended multicenter analysis may further elucidate the changes in EK procedures and the causes of BK in Japan.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

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