July 2018
Volume 59, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2018
Relationship between subjective symptoms of dry eye disease and lifestyle habits: Large-scale clinical research using iPhone application
Author Affiliations & Notes
  • Takenori Inomata
    Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan
  • Masahiro Nakamura
    Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan
  • Yusuke Yoshimura
    Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan
  • Masao Iwagami
    Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan
  • Yoshimune Hirastuka
    Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan
  • Satoshi Hori
    Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan
  • Keiichi Fujimoto
    Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan
  • Yuichi Okumura
    Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan
  • Tina Shiang
    Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan
  • Akira Murakami
    Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Takenori Inomata, Alcon Japan Ltd (F), Hogy Medical Co., Ltd (F), HOYA Co., Ltd (F), Kowa., Ltd (F), Ribomic Co., Ltd (F), ROHTO Pharmaceutical Co.,Ltd (F), Santen Pharmaceutical Co., Ltd (F), SEED Co., Ltd (F), WAKAMOTO Co., Ltd (F); Masahiro Nakamura, None; Yusuke Yoshimura, None; Masao Iwagami, None; Yoshimune Hirastuka, None; Satoshi Hori, None; Keiichi Fujimoto, None; Yuichi Okumura, None; Tina Shiang, None; Akira Murakami, Santen Pharmaceutical Co., Ltd (P), SEED Co., Ltd (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 943. doi:
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      Takenori Inomata, Masahiro Nakamura, Yusuke Yoshimura, Masao Iwagami, Yoshimune Hirastuka, Satoshi Hori, Keiichi Fujimoto, Yuichi Okumura, Tina Shiang, Akira Murakami; Relationship between subjective symptoms of dry eye disease and lifestyle habits: Large-scale clinical research using iPhone application. Invest. Ophthalmol. Vis. Sci. 2018;59(9):943.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We developed a new smartphone application “DryEyeRhythm” for assessing dry eye disease (DED) using ResearchKit, incorporating the Ocular Surface Disease Index (OSDI) questionnaire and lifestyle habit monitoring. The purpose of this study was to examine the relationship between subjective symptoms of DED and lifestyle habits using the iPhone application.

Methods : We conducted an observational study between November 2016 and April 2016, investigating factors including OSDI and lifestyle habits (contact lenses, smoking, screen time, coffee intake, exercise, and sleep). The OSDI measurement in DryEyeRhythm was validated (γ=0.75). We defined an OSDI score greater than 33 as severe DED. We calculated the odds ratio for each lifestyle factor adjusted for age and sex to OSDI scores over 33 using the logistic regression model.

Results : Of the 8,849 participants (median age 23 years, male 62.6%), 2,529 (28.6%) had an OSDI score greater than 33. The age-sex adjusted odds ratio (95% confidence interval) and P value for each lifestyle habit for patients with OSDI scores over 33 are (i) contact lenses, 1.19 (1.08 - 1.31), P <0.001, (ii) smoking, 1.61 (1.42 - 1.82 ), P <0.001, (iii) screen time (every hour / day increase), 1.03 (1.01-1.04), P <0.001, (iv) coffee intake (every 1 cup / day increase), 1.05 (1.00- 1.10), P = 0.041, (v) periodic exercise, 0.87 (0.78 - 0.96), P = 0.006 and vi) sleep time (every hour increase), 0.98 (0.97 - 1.00), P = 0.048.

Conclusions : Our large-scale clinical research using the iPhone application suggests that contact lenses, smoking, longer screen time, and frequent coffee intake may be risk factors for worsening dry eye disease. Regular exercise and more sleep may prevent progression of dry eye disease.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

 

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