July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Coronary artery disease severity and its correlation with retinal blood vessel caliber demonstrated by spectral domain optical coherence tomography
Author Affiliations & Notes
  • Omer Trivizki
    Ophthalmology, Tel Aviv Medical Center,Tel Aviv, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
  • Sharon Armarnik
    Ophthalmology, Meir Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Kfar Saba, Israel
  • Yaron Arbel
    Cardiology, Tel Aviv Medical Center, Tel Aviv, Sackler School of Medicine, Tel Aviv University, Tel Avivv, Israel
  • Amir Rosenblatt
    Ophthalmology, Tel Aviv Medical Center,Tel Aviv, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
  • Rozitsky Vladimir
    Ophthalmology, Tel Aviv Medical Center,Tel Aviv, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
  • Dafna Goldenberg
    Ophthalmology, Tel Aviv Medical Center,Tel Aviv, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
  • Footnotes
    Commercial Relationships   Omer Trivizki, None; Sharon Armarnik, None; Yaron Arbel, None; Amir Rosenblatt, None; Rozitsky Vladimir, None; Dafna Goldenberg, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1094. doi:https://doi.org/
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      Omer Trivizki, Sharon Armarnik, Yaron Arbel, Amir Rosenblatt, Rozitsky Vladimir, Dafna Goldenberg; Coronary artery disease severity and its correlation with retinal blood vessel caliber demonstrated by spectral domain optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1094. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe the correlation between retinal blood vessel diameters as measured by spectral domain optical coherence tomography (SD-OCT) and coronary artery disease (CAD) severity in patients with ischemic heart disease (IHD).

Methods : The study group consisted of 64 (123 eyes) with IHD who underwent an elective coronary angiography and an SD-OCT exam (Spectralis, Heidelberg Engineering, Heidelberg, Germany). Two cubes of seven high-resolution horizontal scans were placed at the superior and inferior borders of the optic disc to include the large temporal retinal vessels. The inter-scan interval was 240 µm. The outer diameter of the main temporal artery and vein was measured manually at distances of 480 µm, 720 µm, 960 µm, 1200 µm and 1440 µm from the optic disc border, superiorly and inferiorly. Archived results from 29 healthy subjects (58 eyes) were used as controls.

Results : The mean ± SD age of the IHD cohort was 66.5 ± 9.9 years. The mean diameters of their upper and lower arteries steadily decreased, from 138.3 ± 13.7 µm and 142.7 ± 14.6 µm, respectively, at 480 µm from the optic disc to 126.3 ± 16.0 µm and 130.9 ± 13.0 µm, respectively, at 1440 µm from the optic disc. The mean diameters of their upper and lower veins steadily decreased, from 161.6 ± 23.2 µm and 164.6 ± 18.3 µm, respectively, at 480 µm from the optic disc to 147.1 ± 17.5 µm and 154.8 ± 16.3 µm, respectively, at 1440 µm from the optic disc. The overall mean artery-to-vein ratio (AVR) of their upper and lower arcades was 0.87 and 0.84, respectively. The female IHD patients had wider mean arterial and vein diameters compared to the controls at all points of measurement, reaching statistical significance in the inferior veins (P < 0.001). The mean AVRs of all IHD patients was smaller at all points of measurement compared to the controls (P < 0.05).

Conclusions : SD-OCT-based retinal vessel diameter analysis of patients with IHD shows significant arterial widening, vein widening and decreased AVR compared to healthy controls. This finding may assist the ophthalmologist in identifying patients at risk for CAD.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

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