July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Therapeutic Effect of Intense Pulsed Light on Ocular Demodicosis
Author Affiliations & Notes
  • Xiaozhao Zhang
    Department of Ophthalmology and Vision Science, The Eye & ENT Hospital of Fudan University , Shang hai, China
    Key Laboratory of Myopia, Ministry of Health, Shanghai, China
  • Lan Gong
    Department of Ophthalmology and Vision Science, The Eye & ENT Hospital of Fudan University , Shang hai, China
    Key Laboratory of Myopia, Ministry of Health, Shanghai, China
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 134. doi:
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      Xiaozhao Zhang, Lan Gong; Therapeutic Effect of Intense Pulsed Light on Ocular Demodicosis. Invest. Ophthalmol. Vis. Sci. 2018;59(9):134.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the effect of M22 intense pulsed light (IPL) for ocular demodicosis in a prospective study.

Methods : Twenty patients with ocular demodicosis were recruited. All participants underwent one IPL treatment. Demodex counts, lid margin abnormalities, conjunctival congestion, tear break up time (TBUT), corneal fluorescence staining, meibomian gland (MG) expressibility, meibum quality, in vivo confocal microscopy examination and subjective symptom scores were assessed on the day before IPL treatment and 30 days following baseline (BL).

Results : IPL treatment significantly decreased the mean mite count/8 lashes assessed by both light microscopy examination (from 23.15 ± 16.24 to 1.5 ± 2.89, P < 0.01) and in vivo confocal microscopy (from 15.6 ± 8.43 to 2.5 ± 4.5, P < 0.01). The successful eradication rate was 75% (15/20). Compared with baseline, thehe ocular surface disease index(OSDI) score, lid margin abnormalities, conjunctival congestion, meibum quality, TBUT and meibum secretion reflectivity (MSR) significantly decreased after treatment (P < 0.05 for each comparison). No significant difference was noted in Schirmer test values, MG expressibility or corneal fluorescence staining before and after treatment (P > 0.05 for each comparison).

Conclusions : Intense pulsed light shows therapeutic potential for ocular demodicosis

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Figure 1:Patients with blepharitis experience ocular demodicosis.A, B. Cylindrical dandruff (CD); C. Conjunctival congestion; D. Corneal fluorescence staining; E, F. Demodex in the hair follicle

Figure 1:Patients with blepharitis experience ocular demodicosis.A, B. Cylindrical dandruff (CD); C. Conjunctival congestion; D. Corneal fluorescence staining; E, F. Demodex in the hair follicle

 

Figure 2:Meibomian gland and ocular Demodex in one patient before and after treatment. A. Demodex organisms were observed in the hair follicle before treatment; B. After treatment, Demodex cannot be observed; C. Before treatment, light grey secretions were observed in a meibomian gland bubble; D. After treatment, black secretions were visible in a meibomian gland bubble.

Figure 2:Meibomian gland and ocular Demodex in one patient before and after treatment. A. Demodex organisms were observed in the hair follicle before treatment; B. After treatment, Demodex cannot be observed; C. Before treatment, light grey secretions were observed in a meibomian gland bubble; D. After treatment, black secretions were visible in a meibomian gland bubble.

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