July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Sustainable Staining of the Xen Gel Stent
Author Affiliations & Notes
  • Jeanie Ling
    Ruiz Department of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, United States
    Robert Cizik Eye Clinic, Houston, Texas, United States
  • Nicholas P Bell
    Ruiz Department of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, United States
    Robert Cizik Eye Clinic, Houston, Texas, United States
  • Robert M Feldman
    Ruiz Department of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, United States
    Robert Cizik Eye Clinic, Houston, Texas, United States
  • Footnotes
    Commercial Relationships   Jeanie Ling, None; Nicholas Bell, Allergan (F); Robert Feldman, Allergan (F)
  • Footnotes
    Support  Hermann Eye Fund
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2050. doi:
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      Jeanie Ling, Nicholas P Bell, Robert M Feldman; Sustainable Staining of the Xen Gel Stent. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2050.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The Xen gel stent (Allergan, Madison, NJ) is one of the newest minimally invasive glaucoma surgery (MIGS) devices. It provides intraocular pressure (IOP) control via subconjunctival bleb formation using an ab interno approach. Due to its small size and light color, placement and revision of the Xen can be challenging. Staining of the stent with dye may enable improved visualization and efficiency of implantation. We evaluated staining of the implant and the sustainability of coloration.

Methods : We stained Xen gel stents with 3 vital dyes preservative-free Trypan blue 1.5 % (Greenpark Compounding Pharmacy, Houston, TX), Brilliant Blue 0.05% (Coomassie Brilliant Blue G 250, Sigma-Aldrich, St. Louis, MO), and indocyanine green (ICG) 0.5% (Cardiogreen Polymethine Dye, Sigma-Aldrich Co.); surgical skin marker (Surgical Marker 1451, Viscot, East Hanover, NJ); and black India ink (Rapidograph ink, Chartpak, Inc., Leeds, MA), green ink (Rapidograph ink), and blue ink (Rapidograph ink). The stained Xen gel stents and an unstained stent were immersed in 2 ml of balanced salt solution (BSS) and washed with agitation at (37oC) for the duration of the experiment. Photographs were taken at Day 0, Day 14, and Day 30.

Results : At Day 0, all stents except the control were stained. At Day 14, the Trypan blue, ICG , black India ink, and green ink stents remained stained; the rest had no visible staining. The stain on the stent marked with surgical marker had dissolved in BSS by Day 14. At Day 30, the Trypan blue, black India ink, and green ink stents remained stained. The ICG stent was lightly stained; the rest had no visible staining.

Conclusions : Trypan blue, ICG, black India ink, and green ink staining can provide sustained coloration of the Xen gel stent. Staining may be beneficial for visibility of the stent during implantation and needle revision.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

At Day 30, the Xen gel stents stained with Trypan blue, indocyanine green (ICG), black India ink, and green ink remained stained.

At Day 30, the Xen gel stents stained with Trypan blue, indocyanine green (ICG), black India ink, and green ink remained stained.

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