July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Changes in Bruch’s membrane opening-minimum rim width after reduction of intraocular pressure in eyes with chronic open-angle glaucoma
Author Affiliations & Notes
  • Tetsuro Takumi
    Toho University Ohashi Medical Center, Tokyo, Japan
    Department of Ophthalmology, Toho University Graduate School of Medicine, Tokyo, Japan
  • Nobuko Enomoto
    Toho University Ohashi Medical Center, Tokyo, Japan
  • Fumihiko Yagi
    Toho University Ohashi Medical Center, Tokyo, Japan
  • Goji Tomita
    Toho University Ohashi Medical Center, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Tetsuro Takumi, None; Nobuko Enomoto, KOWA PHARMACEUTICAL COMPANY LTD (R), Novartis Pharmaceuticals (R), Santen Pharmaceutical Company (R); Fumihiko Yagi, None; Goji Tomita, Alcon Japan Ltd (F), Alcon Japan Ltd (R), Heidelberg Engineering Inc (F), Japan Focus Company Ltd (R), Japan Focus Company Ltd (F), KOWA PHARMACEUTICAL COMPANY LTD (F), KOWA PHARMACEUTICAL COMPANY LTD (R), Pfizer Inc (R), Pfizer Inc (F), Santen Pharmaceutical Company (F), Santen Pharmaceutical Company, Ltd (R), SENJU PHARMACEUTICAL CO., LTD (F), SENJU PHARMACEUTICAL CO., LTD (R), TOPCON CORPORATION (F), TOPCON CORPORATION (R), wakamoto Pharmaceutical Company, Ltd (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2092. doi:
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    • Get Citation

      Tetsuro Takumi, Nobuko Enomoto, Fumihiko Yagi, Goji Tomita; Changes in Bruch’s membrane opening-minimum rim width after reduction of intraocular pressure in eyes with chronic open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2092.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Bruch Membrane’s Opening (BMO), the termination of Bruch’s membrane measured by spectral-domain optical coherence tomography (SD-OCT) is an accurate anatomic boundary of the neuro retinal rim tissue. Using BMO-Minimum Rim Width (BMO-MRW), the shortest distance from the BMO to the inner limiting membrane (ILM) enables clinicians to have high diagnostic performance for open-angle glaucoma. We prospectively investigate alterations of the optic nerve head (ONH) structure using SD-OCT derived BMO-MRW, RNFLT in eyes of open angle glaucoma as well as to investigate the relationship between changes in BMO-MRW and those in the amount of prelaminar tissue displacement after trabeculectomy (TLE).

Methods : A total of 31 eyes of 31 patients which achieved a 20% or more IOP reduction at three months after TLE were included (Age: 68.7±11.9). We measured MRW, RNFLT and BMO Area using SD-OCT before surgery and 3 months postoperatively. BMO and RNFLT were measured in seven areas of ONH (Global, Temporal, Temporal Superior, Temporal Inferior, Nasal, Nasal Superior, Nasal Inferior). Cup size was also evaluated in 2 scans, passing through temporal-superior to nasal –inferior and temporal-inferior to nasal-superior of the ONH(Figure 1). For measuring cup size, we made linear lines from the two ends of the BMO to the corresponding visible edges of the anterior laminar surface and measured the area using Image J. Alterations of MRW, RNFLT, BMO Area and cup size were analyzed by the Wilcoxon's signed rank test. Correlations between MRW, RNFLT, cup size and the reduction of IOP were analyzed by Spearman's rank correlation coefficient.

Results : MRW increased significantly in Global, Temporal Superior and Nasal region (p<0.05), RNFLT didn’t increase in any region, and BMO Area significantly decreased (p=0.022), Cup size decreased significantly in the 2 scans and the mean value (p<0.05). MRW increase and IOP reduction correlated significantly in Global, Temporal and Nasal Inferior region (p=0.045, p=0.002, p=0.041). Cup size reduction and IOP reduction rate correlated significantly in temporal-inferior to nasal-superior line and the mean value of two lines (p=0.010, p=0.037).

Conclusions : MRW increased and its increase correlated with IOP reduction.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.




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