July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Screening Criteria for Retinopathy of Prematurity in Ulaanbaatar, Mongolia
Author Affiliations & Notes
  • Shelbi Olson
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States
    Center for Global Health, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States
  • Tsengelmaa Chuluunbat
    National Center for Maternal and Child Health, Ulaanbaatar, Mongolia
  • Karyn Jonas
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States
  • Munkhuu Bayalag
    National Center for Maternal and Child Health, Ulaanbaatar, Mongolia
  • Chimgee Chuluunkhuu
    Orbis International, New York, New York, United States
  • Hunter Cherwek
    Orbis International, New York, New York, United States
  • Nathan G Congdon
    Orbis International, New York, New York, United States
  • Leslie MacKeen
    The Hospital for Sick Children, Toronto, Ontario, Canada
  • Joelle Hallak
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States
  • Vivien Yap
    Weill Cornell Medical College, New York, New York, United States
  • Susan Ostmo
    Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Wei-Chi Wu
    Chang Gung Memorial Hospital, Taoyuan, Taiwan
  • J. Peter Campbell
    Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Michael F Chiang
    Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Robison Vernon Paul Chan
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States
    Center for Global Health, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States
  • Footnotes
    Commercial Relationships   Shelbi Olson, None; Tsengelmaa Chuluunbat, None; Karyn Jonas, None; Munkhuu Bayalag, None; Chimgee Chuluunkhuu, None; Hunter Cherwek, None; Nathan Congdon, None; Leslie MacKeen, None; Joelle Hallak, None; Vivien Yap, None; Susan Ostmo, None; Wei-Chi Wu, None; J. Peter Campbell, None; Michael Chiang, Clarity Medical Systems (S), Novartis (C); Robison Chan, None
  • Footnotes
    Support  United States Agency for International Development (USAID) Child Blindness Program (CBP); P30 EY001792, Core Grant for Vision Research from the National Institutes of Health, Bethesda, MD; Research to Prevent Blindness (RPB), Unrestricted department grant from RPB, New York, NY; Funding from the Division of Global Ophthalmology, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, IL; Orbis International; UIC College of Medicine Dr. C. M. Craig Fellowship for Summer Research
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2748. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Shelbi Olson, Tsengelmaa Chuluunbat, Karyn Jonas, Munkhuu Bayalag, Chimgee Chuluunkhuu, Hunter Cherwek, Nathan G Congdon, Leslie MacKeen, Joelle Hallak, Vivien Yap, Susan Ostmo, Wei-Chi Wu, J. Peter Campbell, Michael F Chiang, Robison Vernon Paul Chan; Screening Criteria for Retinopathy of Prematurity in Ulaanbaatar, Mongolia. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2748.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Blindness from retinopathy of prematurity (ROP) can be prevented with early identification and timely intervention. Low birthweight (BW) and early gestational age (GA) are the major risk factors for ROP. Neonatal mortality is decreasing in Mongolia, which will require evidence-based screening criteria for ROP. The purpose of this study is to describe BW and GA of children at risk for ROP in a cohort of patients in Mongolia and identify potential evidence-based ROP screening criteria.

Methods : 193 neonates, ≤36 weeks and/or ≤2000g at the National Center for Maternal and Child Health in Ulaanbaatar, Mongolia, were included in this prospective study. ROP screening exams to determine ROP status and severity were performed. Data was collected using a secure web-based system between December 1, 2015 and January 31, 2017. BW and GA were categorized based on their quantile distribution, BW (≤1200g, between 1201 and 1699, and ≥1700) and GA (≤29 weeks, between 30 and 31, and ≥32). Log-binomial regression analysis was performed to determine the relative risk and confidence intervals between BW and ROP status and GA and ROP status.

Results : Seventy-five infants (39%) developed ROP and 44 infants developed Type 2 or worse ROP. Four infants progressed to stage 4 and no children progressed to stage 5. Of those with ROP, the highest severity reached was mild in 31 infants, Type 2 in 14 infants, and Type 1 in 30 infants. The distribution of BW and GA of infants with ROP is shown in Table 1. The relative risk of developing any stage ROP and Type 2 or worse ROP increased as BW and GA decreased (Table 2). The heaviest infant treated had a BW of 2000g and the oldest infant treated had a GA 34 weeks.

Conclusions : The incidence of ROP in Mongolia is similar to other low to middle income countries. ROP was seen in infants with larger BW and older GA relative to high income nations. The distribution of BW and GA in this cohort did not match existing screening criteria in higher income countries, indicating that screening criteria should be based on the population in which it will be implemented. Screening infants ≤34 weeks and/or ≤2000g would capture the cases of treatment-requiring ROP in the group of patients that were analyzed in this study. This recommendation is limited by the assumption that all clinical data was captured accurately and that GA was measured accurately.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×