July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Optical Coherence Tomography Angiography of Inflammatory Choroidal Neovascularization Early Response after Anti-VEGF Treatment
Author Affiliations & Notes
  • WENYI TANG
    Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan University, Shanghai, China
  • Wei Liu
    Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan University, Shanghai, China
  • Gezhi Xu
    Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan University, Shanghai, China
  • Footnotes
    Commercial Relationships   WENYI TANG, None; Wei Liu, None; Gezhi Xu, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2806. doi:
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      WENYI TANG, Wei Liu, Gezhi Xu; Optical Coherence Tomography Angiography of Inflammatory Choroidal Neovascularization Early Response after Anti-VEGF Treatment. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2806.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe the optical coherence tomography angiography (OCTA) features of active inflammatory choroidal neovascularization (CNV) and characterize the early responses of anti-vascular endothelial growth factor (VEGF) treatment for inflammatory CNV.

Methods : OCT angiography images of inflammatory CNV were acquired and analyzed using the RTVue XR Avanti with AngioVue at baseline as well as fluorescein angiography and spectral-domain optical coherence tomography (SD-OCT). OCTA scans were sequentially obtained 1 day before treatment, 1 day, 7 days, 14 days and 30 days after anti-VEGF injection. Changes of the selected area and flow area of CNV on OCTA were measured along with those of the central macular thickness (CMT) on corresponding SD-OCT.

Results : 19 eyes of 18 uveitic patients (mean age: 36.83 ± 10.05 years) presenting with active CNV were included in the prospective case series. The OCTA showed a 100% sensitivity for inflammatory CNV detection in 23 of 23 CNV lesions, revealing prevailing two neovascular phenotypes: vascular loops and intertwined nets. After anti-VEGF injection, as early as the 1-day follow-up, the mean selected area and the mean flow area of inflammatory CNV on OCTA were significantly reduced (both P< 0.05) while the average CMT on SD-OCT did not change until the 7-day follow-up. OCTA was able to detect the reincrease of capillary density and vessel size predominantly in the second phenotype 14-30 days after anti-VEGF injection.

Conclusions : OCTA not only allows for noninvasive detection of inflammatory CNV with a high sensitivity but also facilitates its sequential observation after anti-VEGF treatment. The treatment outcomes are observable at day 1 post treatment. OCTA may be a useful tool for diagnosing inflammatory CNV and evaluating the early response to anti-VEGF treatment.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Figure 1. Optical coherence tomographic angiography of the changes of inflammatory CNV at day 1 post anti-VEGF therapy.

Figure 1. Optical coherence tomographic angiography of the changes of inflammatory CNV at day 1 post anti-VEGF therapy.

 

Figure 2. Optical coherence tomographic angiography of the early evolution of two types of inflammatory CNV after anti-VEGF therapy.

Figure 2. Optical coherence tomographic angiography of the early evolution of two types of inflammatory CNV after anti-VEGF therapy.

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