July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Vascular remodeling of choroidal neovascularization after anti-VEGF therapy visualized on optical coherence tomography angiography
Author Affiliations & Notes
  • Alexandra Miere
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
  • Pauline Butori
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
  • Salomon Y Cohen
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
  • OudI Semoun
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
  • Vittorio Capuano
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
  • Camille Jung
    Clinical Research Center, GRC Macula, and Biological Ressources Center, Centre Hospitalier Intercommunal de créteil, Créteil, France
  • Eric H Souied
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
  • Footnotes
    Commercial Relationships   Alexandra Miere, None; Pauline Butori, None; Salomon Cohen, None; OudI Semoun, None; Vittorio Capuano, None; Camille Jung, None; Eric Souied, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2807. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Alexandra Miere, Pauline Butori, Salomon Y Cohen, OudI Semoun, Vittorio Capuano, Camille Jung, Eric H Souied; Vascular remodeling of choroidal neovascularization after anti-VEGF therapy visualized on optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2807.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To qualitatively and quantitatively describe the changes in choroidal neovascularization (CNV) flow pattern after anti-vascular endothelial growth factor (anti-VEGF) therapy, by means of optical coherence tomography angiography (OCTA).

Methods : Consecutive patients with neovascular age-related macular degeneration (AMD) underwent multimodal imaging, including OCTA at baseline and at last visit. High flow networks in the choriocapillaris segmentation of OCTA were qualitatively and quantitatively analyzed at baseline and at follow up, in order to characterize vascular flow changes after anti-VEGF treatment and to correlate these changes with final exudation signs on SD-OCT.

Results : Seventeen eyes were included. Mean follow-up was of 11.7 +/- 3.3 months. Baseline images showed: 6 medusa pattern (35.3%), 4 seafan pattern (23.5%) and 7 indistinct network patterns (41.2%). Mean CNV area at baseline was 1.58 +/- 1.72 mm2. Final OCTA images revealed a decrease in CNV total area of 21.6%. In 6/17 eyes the baseline neovascular pattern was unchanged; these cases were associated with exudation at the final SD-OCT examination (p=0.034) and a decrease in CNV area of 34.1 %. Conversely, in 11/17 eyes (64.7 %), the initial pattern had changed to a pruned vascular tree pattern, with variable exudative status on SD-OCT at the final visit and a decrease in total CNV area of 0.07%.

Conclusions : Vascular flow remodeling induced by anti-VEGF treatment can be analyzed using OCTA. OCTA may help to accurately evaluate treatment response and to recognize the patterns usually associated with recurrent exudative activity.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

CNV patterns in OCTA. (1)central feeder vessel, (2)main vascular trunks, (3)tiny capillaries, (4)a circular peripheral anastomosis, (5)dark halo.
A. “Medusa” pattern
B. “Seafan” pattern
C. “Indistinct network” pattern
D. “Pruned vascular tree” pattern

CNV patterns in OCTA. (1)central feeder vessel, (2)main vascular trunks, (3)tiny capillaries, (4)a circular peripheral anastomosis, (5)dark halo.
A. “Medusa” pattern
B. “Seafan” pattern
C. “Indistinct network” pattern
D. “Pruned vascular tree” pattern

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×