July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Evaluation of focal damage of retinal pigment epithelium layer in retinal pigment epithelium detachment by polarization sensitive optical coherence tomography
Author Affiliations & Notes
  • Masahiro Miura
    Dept of Ophthalmology, Tokyo Med Univ, Ibaraki Med Ctr, Inashiki, IBARAKI, Japan
  • Shuichi Makita
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
  • Yoshiaki Yasuno
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
  • Rieko Mihara
    Dept of Ophthalmology, Tokyo Med Univ, Ibaraki Med Ctr, Inashiki, IBARAKI, Japan
  • Toshihiro Mino
    Topcon, Tokyo, Japan
  • Tatsuo Yamaguchi
    Topcon, Tokyo, Japan
  • Satoshi Sugiyama
    Tomey, Nagoya, Japan
  • Takuya Iwasaki
    Dept of Ophthalmology, Tokyo Med Univ, Ibaraki Med Ctr, Inashiki, IBARAKI, Japan
  • Hiroshi Goto
    Ophthalmology, Tokyo Medical University, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Masahiro Miura, Alcon (F), Allergan (F), Bayer (F), Novartis (F), Novartis (R), Santen (F), Santen (R); Shuichi Makita, KAO (F), Nidek (F), Tomey (F), Tomey (P), Topcon (F); Yoshiaki Yasuno, KAO (F), Nidek (F), Tomey (F), Tomey (P), Topcon (F); Rieko Mihara, None; Toshihiro Mino, Topcon (E); Tatsuo Yamaguchi, Topcon (E); Satoshi Sugiyama, Tomey (E); Takuya Iwasaki, None; Hiroshi Goto, None
  • Footnotes
    Support  KAKENHI 15K10905
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3256. doi:
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    • Get Citation

      Masahiro Miura, Shuichi Makita, Yoshiaki Yasuno, Rieko Mihara, Toshihiro Mino, Tatsuo Yamaguchi, Satoshi Sugiyama, Takuya Iwasaki, Hiroshi Goto; Evaluation of focal damage of retinal pigment epithelium layer in retinal pigment epithelium detachment by polarization sensitive optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3256.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We hypothesized that depolarization in polarimetry imaging is useful to evaluate the retinal pigment epithelium (RPE). In this study, we evaluated the focal damage of RPE layer in RPE detachment (PED) using polarization sensitive optical coherence tomography (PS-OCT).

Methods : We prospectively examined 54 eyes of 47 patients with PED in age-related macular degeneration, including 35 eyes of serous PED and 19 eyes of drusenoid PED. Degree of polarization uniformity (DOPU) was calculated from the data set of PS-OCT with 1-μm probing wavelength. Melanin-containing structures like RPE are source of depolarization, and induce low DOPU in PS-OCT. Each PS-OCT image was compared with auto-fluorescence image at 480 nm (SW-AF) and 780 nm (NIR-AF). Focal RPE damage was defined by the presence of focal defect of depolarization in PS-OCT image at RPE-basal lamina band without RPE tear, hyper-transmission below the RPE line in standard OCT images, and hypo-AF in SW-AF and NIR-AF images at corresponding location. Volumes of PED and intraretinal hyper-reflective foci (HRF) were calculated using standard OCT images, and compared with the existence of focal RPE damage

Results : Focal RPE damages were detected in 22 of 54 eyes (41 %) [14 of 35 eyes (40 %) in serous PED and 8 of 19 eyes (42%) in drusenoid PED]. Among them, standard OCT images did not show obvious change in RPE-basal lamina band at focal RPE damage in 18 of 22 eyes (82 %) [12 of 14 eyes (86 %) in serous PED and 6 of 8 eyes (75 %) in drusenoid PED]. PED volume did not show any significant differences by the presence of focal RPE damage. In serous PED group, HRF volume in the eyes with focal RPE damage (mean: 0.0070 mm3) was significantly larger than the eyes without focal RPE damage (mean: 0.0020 mm3) (P = 0.009). Presence of RPE migrations at these HRF were confirmed by low DOPU in PS-OCT, and hyper-AF in both NIR-AF and SW-AF images at corresponding location.

Conclusions : PS-OCT is more sensitive than standard OCT for detection of focal RPE damage. In serous PED, the development of focal RPE damage is related with intraretinal RPE migration.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Focal RPE damage with intraretinal RPE migration. White arrows indicate the defect of depolarization in PS-OCT image at RPE-basal lamina band, and hypo-AF in both NIR-AF and SW-AF images at corresponding location.

Focal RPE damage with intraretinal RPE migration. White arrows indicate the defect of depolarization in PS-OCT image at RPE-basal lamina band, and hypo-AF in both NIR-AF and SW-AF images at corresponding location.

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