July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Aqueous humor cytokine levels in patients with diabetic macular edema refractory to intravitreal anti-VEGF treatment and a dexamethasone implant
Author Affiliations & Notes
  • Yoon seob Sim
    Ophthalmology, St. Mary's hospital, Seoul, Korea (the Republic of)
  • Jinwoo Kwon
    St.Vincent hospital, Suwon, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Yoon seob Sim, None; Jinwoo Kwon, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4829. doi:
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    • Get Citation

      Yoon seob Sim, Jinwoo Kwon; Aqueous humor cytokine levels in patients with diabetic macular edema refractory to intravitreal anti-VEGF treatment and a dexamethasone implant. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4829.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the association between aqueous cytokine levels and responsiveness to intravitreal bevacizumab(IVB) injection and a dexamethasone implant in patients with diabetic macular edema(DME)

Methods : We measured concentrations of interleukin (IL)-1β, IL-2, IL-8, IL-10, IL-17, placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) in the aqueous humors of three groups with center-involved DME that exhibited a good response to IVB, a poor response to IVB but a good response to a dexamethasone implant, and poor responses to both agents. We also used logistic regression analyses to identify preoperative factors related to responsiveness

Results : Analysis of biomarker differences among the three groups revealed a significant difference in IL-8 level only (p = 0.012). IL-8 level and the initial central subfield thickness were associated with IVB responsiveness (p = 0.02 and 0.02, respectively). Poor responses to IVB and the dexamethasone implant were associated with the aqueous humor IL-10 level and the logMAR best corrected visual acuity (BCVA) at the initial visit (p = 0.048 and 0.047, respectively). However other aqueous humor biomarkers and the level of glycated hemoglobin were not associated with responsiveness to IVB and the dexamethasone implant

Conclusions : The aqueous IL-10 level and BCVA at the initial visit were associated with poor responses to both IVB and a dexamethasone implant

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Plot of final model with stepwise backward logistic regression analysis for responsiveness to intravitreal Bevacizumab injection.
*p<0.05

Plot of final model with stepwise backward logistic regression analysis for responsiveness to intravitreal Bevacizumab injection.
*p<0.05

 

Plot of final model with stepwise backward logistic regression analysis for poor responsiveness to intravitreal Bevacizumab injection and dexamethasone implant.
*p<0.05

Plot of final model with stepwise backward logistic regression analysis for poor responsiveness to intravitreal Bevacizumab injection and dexamethasone implant.
*p<0.05

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