Abstract
Purpose :
To determine the association between aqueous cytokine levels and responsiveness to intravitreal bevacizumab(IVB) injection and a dexamethasone implant in patients with diabetic macular edema(DME)
Methods :
We measured concentrations of interleukin (IL)-1β, IL-2, IL-8, IL-10, IL-17, placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) in the aqueous humors of three groups with center-involved DME that exhibited a good response to IVB, a poor response to IVB but a good response to a dexamethasone implant, and poor responses to both agents. We also used logistic regression analyses to identify preoperative factors related to responsiveness
Results :
Analysis of biomarker differences among the three groups revealed a significant difference in IL-8 level only (p = 0.012). IL-8 level and the initial central subfield thickness were associated with IVB responsiveness (p = 0.02 and 0.02, respectively). Poor responses to IVB and the dexamethasone implant were associated with the aqueous humor IL-10 level and the logMAR best corrected visual acuity (BCVA) at the initial visit (p = 0.048 and 0.047, respectively). However other aqueous humor biomarkers and the level of glycated hemoglobin were not associated with responsiveness to IVB and the dexamethasone implant
Conclusions :
The aqueous IL-10 level and BCVA at the initial visit were associated with poor responses to both IVB and a dexamethasone implant
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.