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Rasik Behari Vajpayee, Prema Finn, Graeme Pollock; Postoperative detection of unusual pathology in Donor Corneal Tissue: A Case Series. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5731. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To report a series of cases where donor corneal tissue were found to have posoperatively unusal and previously undetected pathology
Three cases that were found to have unusal pathology in transplanted corneas underwent comprehensive clinical examination including a detailed rexamination of ocular and systemic histories of donors. Besides clinical exmination of transplanted cornes, an anterior segment OCT was performed to detect the possilbe nature and depth of the pathology.
Three cases of keratoconus had corneal transplantation done for keratoconus. In two eyes a Predescematic DALK was performed and one eye underwent a penetrating keratoplasty after a failed attempt of Big Bubble DALK. All donor corneas were preserved using organ cuture method. Postoperatively, a faint anterior stromal haze was detected in donor corneal lenticules of all three cases. Anterior segment OCT demonstrated presence of mid stromal well defined haze extending across the corneas. The ocular and systemic medical history of the donors were unremarkable. There was no history of any corneal surgery including refractive surgery in any of the donors.
This is the first report of occurence of unusual pathology in donor corneal tissues that went undetected despite taking a detailed history from donor families and examination of the corneal tissue by Eye Bank personnel. Donor corneal tissue screening protocols need to be strengthened further with incorporation of Corneal OCT examination to prevent inadvertant utilization of suboptimal donor corneal tissue.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
Stromal Haze in Transplanted Cornea
Corneal OCT Of Grafted Cornea
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