July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Central, Paracentral and Near-Peripheral Retinal Response to Chromatic Blur
Author Affiliations & Notes
  • Muteb Alanazi
    College of Optometry, Pacific University, Forest Grove, Oregon, United States
    College of Applied Medical Sciences, Optometry Department, King Saud University, Riyadh, Riyadh, Saudi Arabia
  • Jeung Kim
    College of Optometry, Pacific University, Forest Grove, Oregon, United States
  • Footnotes
    Commercial Relationships   Muteb Alanazi, None; Jeung Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5805. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Muteb Alanazi, Jeung Kim; Central, Paracentral and Near-Peripheral Retinal Response to Chromatic Blur. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5805.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To investigate the impact of chromatic blur with positive and negative optical defocus on retinal electrical response using multifocal-electroretinogram (mf-ERG).

Methods : Eight adult emmetropes (aged 22 to 29 years) with normal ocular health were enrolled in the study. Multifocal-ERG was performed six times on both eyes according to the following conditions: in focus (focused on retina), positive defocus (+2D) and negative defocus (-2D) conditions with short-pass (blue) and long-pass (red) filters. Two neutral density filters that matched the transmittance of each colored filter were used as a control. The mf-ERG instrument (Diagnosys LLC) was used per manufacturer's protocol. Two drops of 1% Cyclopentolate ophthalmic solution were instilled with 5-minute interval for complete cycloplegia. The mf-ERG stimulus pattern subtended 60 degrees horizontally and vertically at a working distance of 33 cm. The amplitudes and implicit times of the P1 wave component were analyzed by grouping the responses into five concentric rings.

Results : Among the experimental conditions, the P1 amplitude demonstrated a significant difference between red and blue filters in the central ring in all three conditions (P=0.002). The interaction between color filters and type of defocus was statistically significant (p= 0.045). With the red filter, positive defocus showed higher P1 amplitude compared to negative defocus, whereas the blue filter showed higher P1 amplitude with negative defocus than with positive defocus (Figure 1). The implicit time of P1 of all rings was not significantly different (P=0.9).

Conclusions : The findings of this study suggest that the change in the P1 amplitude of the retinal response was consistent with ocular chromatic aberration. Previous studies have shown the paracentral and near-peripheral retina is able to differentiate between positive and negative defocus. Based on this pilot study, chromatic aberration could be the mechanism the retina uses to identify and differentiate positive from negative defocus.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Figure 1. Mean change in P1 amplitude under positive and negative defocus conditions in paracentral and near-peripheral retina. The error bars indicate the 84% confidence interval. The asterisks (*) indicate a statistically significant difference (P< 0.05).

Figure 1. Mean change in P1 amplitude under positive and negative defocus conditions in paracentral and near-peripheral retina. The error bars indicate the 84% confidence interval. The asterisks (*) indicate a statistically significant difference (P< 0.05).

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×