Abstract
Purpose :
To compare the anterior and posterior choroidal thickness (ACT and PCT) in primary open-angle glaucoma (POAG), primary angle-closure disease (PACD), and healthy control subjects.
Methods :
A total of 29 POAG patients (56 eyes), 37 PACD patients (64 eyes), and 34 healthy volunteers (68 eyes) were enrolled in this study; 50 POAG eyes were divided into 25 early/moderate-stage and 25 advanced-stage eyes by visual field loss, while 64 PACD eyes were classified as: (1) primary angle-closure suspect (PACS), 8 eyes;(2) primary angle-closure (PAC), 18 eyes;(3) primary angle-closure glaucoma (PACG), 38 eyes. Ultrasound biomicroscopy (UBM) was used to measure the ACT at a distance of 4 mm from the root of iris in all participants. ACT and PCT were measured using UBM and swept-source optical coherence tomography (SS-OCT), respectively. A 4-mm distance from the iris root was self-defined as the anterior choroid that well matched the real anterior choroid.
Results :
Both the POAG (0.4525±0.05135 mm) and PACD (0.3811±0.05250 mm) eyes had a thicker anterior choroid than healthy eyes (0.2994±0.04995 mm) measured by UBM (P<0.01). Compared to early/moderate stage eyes of POAG, advanced stage eyes had similar ACT (P>0.05). PACG eyes had a thinner anterior choroid than PAC/PACS eyes (P<0.05). However, no statistically significant difference was noted for POAG, PACD, and normal control eyes’ PCT using SS-OCT (P>0.05).
Conclusions :
POAG/PACD eyes had a thicker anterior choroid than the controls. However, there was no significant difference in the PCT among the groups. The anterior choroid might play a role in the pathogenesis of glaucoma, warranting further investigation.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.