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Xiulan Zhang, Fei Li, Kai Gao; Anterior choroidal thickness increased in POAG and PACD eyes evidenced by UBM and SS-OCT. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5897.
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To compare the anterior and posterior choroidal thickness (ACT and PCT) in primary open-angle glaucoma (POAG), primary angle-closure disease (PACD), and healthy control subjects.
A total of 29 POAG patients (56 eyes), 37 PACD patients (64 eyes), and 34 healthy volunteers (68 eyes) were enrolled in this study; 50 POAG eyes were divided into 25 early/moderate-stage and 25 advanced-stage eyes by visual field loss, while 64 PACD eyes were classified as: (1) primary angle-closure suspect (PACS), 8 eyes;(2) primary angle-closure (PAC), 18 eyes;(3) primary angle-closure glaucoma (PACG), 38 eyes. Ultrasound biomicroscopy (UBM) was used to measure the ACT at a distance of 4 mm from the root of iris in all participants. ACT and PCT were measured using UBM and swept-source optical coherence tomography (SS-OCT), respectively. A 4-mm distance from the iris root was self-defined as the anterior choroid that well matched the real anterior choroid.
Both the POAG (0.4525±0.05135 mm) and PACD (0.3811±0.05250 mm) eyes had a thicker anterior choroid than healthy eyes (0.2994±0.04995 mm) measured by UBM (P<0.01). Compared to early/moderate stage eyes of POAG, advanced stage eyes had similar ACT (P>0.05). PACG eyes had a thinner anterior choroid than PAC/PACS eyes (P<0.05). However, no statistically significant difference was noted for POAG, PACD, and normal control eyes’ PCT using SS-OCT (P>0.05).
POAG/PACD eyes had a thicker anterior choroid than the controls. However, there was no significant difference in the PCT among the groups. The anterior choroid might play a role in the pathogenesis of glaucoma, warranting further investigation.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
Figure 1. Ultrasound biomicroscopy (UBM) image showing the measurement of the CT4. Through the root of the iris, draw a line parallel with the inner surface of the sclera. Use the manual segmentation function to delineate the posterior edge of the pars plana of the ciliary body and the sclerochoroidal interface. CT4 is the thickness of the choroid at a distance of 4 mm from the root of the iris.
Figure 2. Swept-source OCT image showing the measurements of posterior choroidal thickness (PCT). (A) PCT map of the 6×6-mm area centered on the fovea was created. (B) Automatic delineate of the chorioscleral border made using automatic built-in software of SS-OCT in one of the B-scan images of the 3D data set. (C) The choroidal topographic map of the 6×6-mm area.
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