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Bongjoon Choi; Noninvasive assessment of tear film and corneal wavefront change of 3% Diquafosol ophthalmic solution for patients with dry eye after cataract surgery. Invest. Ophthalmol. Vis. Sci. 2018;59(9):944.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the efficacies of 3% diquafosol and 0.1% sodium hyaluronate in patients with dry eye after cataract surgery using the noninvasive keratograph 5M (Oculus K5M) and OPD-Scan III.
120 eyes of 92 dry eye patients who had undergone cataract surgery were enrolled and randomly divided into a diquafosol group (60 eyes) and a sodium hyaluronate group(60 eyes). Diquafosol, an activator of the P2Y2 receptor, promotes mucin secretion from the conjunctival tissue and tear secretion. Both groups instilled each eye drop from postoperative day 1 to postoperative week 8. The tear meniscus height (TMH), first non-invasive keratograph break-up time (f-NIKBUT) and average non-invasive keratograph break-up time (avg-NIKBUT) were measured at 1, 4 and 8 weeks postoperatively using the noninvasive Keratograph 5M. Corneal wavefront aberrations over 3mm and 5mm zone including total higher order aberration, coma, trefoil, spherical aberration, and the corneal optical quality parameters including modulation transfer function (MTF), Point-spread function (PSF) were measured using an OPD-Scan III.
There were no significant difference in TMH and NIKBUT between 2 groups at 1 week. TMH, f-NIKBUT and avg-NIKBUT of the diquafosol group was significantly higher than the sodium hyaluronate group at 4 weeks and 8 weeks. The diquafosol group showed statistically significant improvement in TMH, f-NIKBUT and avg-NIKBUT at 4 weeks and 8 weeks after surgery than at baseline. The sodium hyaluronate group showed no significant improvements in the TMH, f-NIKBUT and avg-NIKBUT throughout the study period. There were no significant difference in the corneal wavefront aberrations, MTF, and PSF between the 2 groups at 1, 4, and 8 weeks.
Treatment with 3% Diquafosol ophthalmic solution was shown to be an effective treatment for improvements of tear film stability and tear height for the patients with dry eye after cataract surgery.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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